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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model.

Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 x and 10 x MIC).[1]

References

  1. Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model. Cottagnoud, P., Gerber, C.M., Acosta, F., Cottagnoud, M., Neftel, K., Täuber, M.G. J. Antimicrob. Chemother. (2000) [Pubmed]
 
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