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Chemical Compound Review

AC1NSFK6     (6R,7S)-7-[[(2E)-2-(2-amino- 1,3-thiazol-4...

Synonyms: BSPBio_002274, AC1Q6LOG, BIDD:GT0741, FT-0603014, Ro 15-2254, ...
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Disease relevance of ceftriaxone


Psychiatry related information on ceftriaxone


High impact information on ceftriaxone


Chemical compound and disease context of ceftriaxone


Biological context of ceftriaxone


Anatomical context of ceftriaxone

  • Ceftriaxone-associated gallbladder sludge: what's in a name [17]?
  • It was concluded that the development of ceftriaxone-induced biliary sludge is a solubility problem that occurs in patients receiving high-dose treatment (greater than or equal to 2 g) [18].
  • Biliary secretion of unbiotransformed ceftriaxone occurs at high concentrations; secondary Ca2+ entry results in the formation of supersaturated canalicular bile and subsequent precipitation as a calcium salt in the biliary tract [19].
  • Ceftriaxone for once-a-day therapy of urinary tract infections [20].
  • The in vivo effects of ceftriaxone on neutrophil functions and T-cell subsets were investigated before and 30 minutes after injection on the first and third days [16].

Associations of ceftriaxone with other chemical compounds


Gene context of ceftriaxone


Analytical, diagnostic and therapeutic context of ceftriaxone


  1. Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. Dattwyler, R.J., Luft, B.J., Kunkel, M.J., Finkel, M.F., Wormser, G.P., Rush, T.J., Grunwaldt, E., Agger, W.A., Franklin, M., Oswald, D., Cockey, L., Maladorno, D. N. Engl. J. Med. (1997) [Pubmed]
  2. Ceftriaxone-resistant salmonella infection acquired by a child from cattle. Fey, P.D., Safranek, T.J., Rupp, M.E., Dunne, E.F., Ribot, E., Iwen, P.C., Bradford, P.A., Angulo, F.J., Hinrichs, S.H. N. Engl. J. Med. (2000) [Pubmed]
  3. Meningitis due to ceftriaxone-resistant Streptococcus pneumoniae. Lonks, J.R., Durkin, M.R., Meyerhoff, A.N., Medeiros, A.A. N. Engl. J. Med. (1995) [Pubmed]
  4. A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children. Schaad, U.B., Suter, S., Gianella-Borradori, A., Pfenninger, J., Auckenthaler, R., Bernath, O., Cheseaux, J.J., Wedgwood, J. N. Engl. J. Med. (1990) [Pubmed]
  5. A comparison of single-dose cefixime with ceftriaxone as treatment for uncomplicated gonorrhea. The Gonorrhea Treatment Study Group. Handsfield, H.H., McCormack, W.M., Hook, E.W., Douglas, J.M., Covino, J.M., Verdon, M.S., Reichart, C.A., Ehret, J.M. N. Engl. J. Med. (1991) [Pubmed]
  6. Comparison of ceftriaxone and traditional therapy of bacterial meningitis. Congeni, B.L. Antimicrob. Agents Chemother. (1984) [Pubmed]
  7. Increased mortality and spatial memory deficits in TNF-alpha-deficient mice in ceftriaxone-treated experimental pneumococcal meningitis. Gerber, J., Böttcher, T., Hahn, M., Siemer, A., Bunkowski, S., Nau, R. Neurobiol. Dis. (2004) [Pubmed]
  8. The isolation of antibiotic-resistant salmonella from retail ground meats. White, D.G., Zhao, S., Sudler, R., Ayers, S., Friedman, S., Chen, S., McDermott, P.F., McDermott, S., Wagner, D.D., Meng, J. N. Engl. J. Med. (2001) [Pubmed]
  9. Pseudolithiasis and intractable hiccups in a boy receiving ceftriaxone. Bonioli, E., Bellini, C., Tomà, P. N. Engl. J. Med. (1994) [Pubmed]
  10. Laboratory-based surveillance of Salmonella serotype Typhi infections in the United States: antimicrobial resistance on the rise. Ackers, M.L., Puhr, N.D., Tauxe, R.V., Mintz, E.D. JAMA (2000) [Pubmed]
  11. Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase. Dunne, E.F., Fey, P.D., Kludt, P., Reporter, R., Mostashari, F., Shillam, P., Wicklund, J., Miller, C., Holland, B., Stamey, K., Barrett, T.J., Rasheed, J.K., Tenover, F.C., Ribot, E.M., Angulo, F.J. JAMA (2000) [Pubmed]
  12. Randomised comparison of chloramphenicol, ampicillin, cefotaxime, and ceftriaxone for childhood bacterial meningitis. Finnish Study Group. Peltola, H., Anttila, M., Renkonen, O.V. Lancet (1989) [Pubmed]
  13. HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes. Zanni, M.P., von Greyerz, S., Schnyder, B., Brander, K.A., Frutig, K., Hari, Y., Valitutti, S., Pichler, W.J. J. Clin. Invest. (1998) [Pubmed]
  14. Variability of ceftriaxone pharmacokinetics in hospitalized patients with severe infections. Joos, B., Luethy, R., Muehlen, E., Siegenthaler, W. Am. J. Med. (1984) [Pubmed]
  15. Pharmacokinetics of ceftriaxone in patients with renal and liver insufficiency and correlations with a physiologic nonlinear protein binding model. Stoeckel, K., Koup, J.R. Am. J. Med. (1984) [Pubmed]
  16. Influence of ceftriaxone on natural defense systems. Gialdroni Grassi, G., Fietta, A., Sacchi, F., Derose, V. Am. J. Med. (1984) [Pubmed]
  17. Ceftriaxone-associated gallbladder sludge: what's in a name? Palmer, R.H. Gastroenterology (1991) [Pubmed]
  18. Pathogenesis of ceftriaxone-associated biliary sludge. In vitro studies of calcium-ceftriaxone binding and solubility. Shiffman, M.L., Keith, F.B., Moore, E.W. Gastroenterology (1990) [Pubmed]
  19. Concentrative biliary secretion of ceftriaxone. Inhibition of lipid secretion and precipitation of calcium ceftriaxone in bile. Xia, Y., Lambert, K.J., Schteingart, C.D., GU, J.J., Hofmann, A.F. Gastroenterology (1990) [Pubmed]
  20. Ceftriaxone for once-a-day therapy of urinary tract infections. Childs, S.J., Wells, W.G., Mirelman, S. Am. J. Med. (1984) [Pubmed]
  21. Antimicrobial susceptibility testing of Neisseria gonorrhoeae and implications for epidemiology and therapy. Fekete, T. Clin. Microbiol. Rev. (1993) [Pubmed]
  22. Treatment of Lyme arthritis. Steere, A.C., Levin, R.E., Molloy, P.J., Kalish, R.A., Abraham, J.H., Liu, N.Y., Schmid, C.H. Arthritis Rheum. (1994) [Pubmed]
  23. Management of community-acquired pneumonia in the era of pneumococcal resistance: a report from the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group. Heffelfinger, J.D., Dowell, S.F., Jorgensen, J.H., Klugman, K.P., Mabry, L.R., Musher, D.M., Plouffe, J.F., Rakowsky, A., Schuchat, A., Whitney, C.G. Arch. Intern. Med. (2000) [Pubmed]
  24. Antibiotic prophylaxis in biliary tract surgery. Ciprofloxacin versus ceftriaxone. Kujath, P. Am. J. Med. (1989) [Pubmed]
  25. Diffusibility of the newer cephalosporins into human interstitial fluids. Tan, J.S., Salstrom, S.J., File, T.M. Am. J. Med. (1984) [Pubmed]
  26. Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. Echchannaoui, H., Frei, K., Schnell, C., Leib, S.L., Zimmerli, W., Landmann, R. J. Infect. Dis. (2002) [Pubmed]
  27. The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis. París, M.M., Hickey, S.M., Trujillo, M., Ahmed, A., Olsen, K., McCracken, G.H. J. Infect. Dis. (1997) [Pubmed]
  28. Antibiotics and production of granulocyte-macrophage colony-stimulating factor by human bronchial epithelial cells in vitro. A comparison of cefodizime and ceftriaxone. Pacheco, Y., Hosni, R., Dagrosa, E.E., Gormand, F., Guibert, B., Chabannes, B., Lagarde, M., Perrin-Fayolle, M. Arzneimittel-Forschung. (1994) [Pubmed]
  29. Modulation of cytokines and chemokines, limited pulmonary vascular bed permeability, and prevention of septicemia and death with ceftriaxone and interleukin-10 in pneumococcal pneumonia. Wang, E., Simard, M., Ouellet, N., Bergeron, Y., Beauchamp, D., Bergeron, M.G. J. Infect. Dis. (2000) [Pubmed]
  30. Correlation between ceftriaxone resistance of Salmonella enterica serovar Typhimurium and expression of outer membrane proteins OmpW and Ail/OmpX-like protein, which are regulated by BaeR of a two-component system. Hu, W.S., Li, P.C., Cheng, C.Y. Antimicrob. Agents Chemother. (2005) [Pubmed]
  31. Comparative study of ceftriaxone and spectinomycin for treatment of uncomplicated gonorrhoea in men. Handsfield, H.H., Murphy, V.L. Lancet (1983) [Pubmed]
  32. Ceftriaxone-associated gallbladder sludge. Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate. Park, H.Z., Lee, S.P., Schy, A.L. Gastroenterology (1991) [Pubmed]
  33. Treatment of late Lyme borreliosis--randomised comparison of ceftriaxone and penicillin. Dattwyler, R.J., Halperin, J.J., Volkman, D.J., Luft, B.J. Lancet (1988) [Pubmed]
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