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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Every-other-day acetylmethadol disturbs circadian cycles of human motility.

1-Alpha-acetylmethadol (LAAM) maintenance treatment has been proposed as a favorable alternative to methadone maintenance. With an unobtrusive actometer we recorded two successive 24-h cycles of spontaneous motor activity from 12 patients receiving LAAM every other day, and from five receiving methadone every day. LAAM patients were about 50% more active on days of drug administration than on no-dose days (P less than 0.001). There were no significant day-to-day differences in motility of methadone patients. LAAM administered every other day may significantly modify the human circadian rhythm of spontaneous motility; further research is thus needed before this treatment is widely adopted.[1]

References

  1. Every-other-day acetylmethadol disturbs circadian cycles of human motility. Crowley, T.J., Jones, R.H., Hydinger-Macdonald, M.J., Lingle, J.R., Wagner, J.E., Egan, D.J. Psychopharmacology (Berl.) (1979) [Pubmed]
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