Chemical Compound Review:
Orlaam [(3S,6S)-6-dimethylamino-4,4- diphenyl...
Synonyms:
LAAM, Levomethadyl, CHEMBL1514, SureCN93805, CHEBI:6441, ...
- Treating opioid dependence. Growing implications for primary care. Krantz, M.J., Mehler, P.S. Arch. Intern. Med. (2004)
- Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. Kharasch, E.D., Whittington, D., Hoffer, C., Krudys, K., Craig, K., Vicini, P., Sheffels, P., Lalovic, B. Clinical pharmacokinetics. (2005)
- Effect of alteration of metabolism on the analgesic activity, toxicity, distribution and excretion of l-alpha-acetylmethadol in the rat. Roerig, D.L., Hasegawa, A.T., Wang, R.I. J. Pharmacol. Exp. Ther. (1977)
- Outcome of pregnancy in rats chronically exposed to 1-alpha-acetylmethadol (LAAM). Lichtblau, L., Sparber, S.B. J. Pharmacol. Exp. Ther. (1981)
- Relative potency of levo-alpha-acetylmethadol and methadone in humans under acute dosing conditions. Eissenberg, T., Stitzer, M.L., Bigelow, G.E., Buchhalter, A.R., Walsh, S.L. J. Pharmacol. Exp. Ther. (1999)
- Chromosomes in patients receiving methadone and methadyl acetate. Matsuyama, S.S., Charuvastra, V.C., Jarvik, L.F., Fu, T.K., Sanders, K., Yen, F.S. Arch. Gen. Psychiatry (1978)
- A clinical, controlled study of l-alpha-acetylmethadol in the treatment of narcotic addiction. Marcovici, M., O'Brien, C.P., McLellan, A.T., Kacian, J. The American journal of psychiatry. (1981)
- The substance-using human immunodeficiency virus patient: approaches to outpatient management. O'Connor, P.G., Samet, J.H. Am. J. Med. (1996)
- Every-other-day acetylmethadol disturbs circadian cycles of human motility. Crowley, T.J., Jones, R.H., Hydinger-Macdonald, M.J., Lingle, J.R., Wagner, J.E., Egan, D.J. Psychopharmacology (Berl.) (1979)
- Dose-response analysis of opioid cross-tolerance and withdrawal suppression during LAAM maintenance. Houtsmuller, E.J., Walsh, S.L., Schuh, K.J., Johnson, R.E., Stitzer, M.L., Bigelow, G.E. J. Pharmacol. Exp. Ther. (1998)
- Induction with levomethadyl acetate: safety and efficacy. Jones, H.E., Strain, E.C., Bigelow, G.E., Walsh, S.L., Stitzer, M.L., Eissenberg, T., Johnson, R.E. Arch. Gen. Psychiatry (1998)
- Acute effects of ethanol on hepatic uptake and distribution of narcotics in the isolated perfused rabbit liver. Kreek, M.J., Rothschild, M.A., Oratz, M., Mongelli, J., Handley, A.C. Hepatology (1981)
- Plasma l-alpha-Acetylmethadol (LAAM) after acute and chronic administration. Henderson, G.L., Wilson, B.K., Lau, D.H. Clin. Pharmacol. Ther. (1977)
- The naloxone test for opiate dependence. Judson, B.A., Himmelberger, D.U., Goldstein, A. Clin. Pharmacol. Ther. (1980)
- Toxicological evaluation of mu-agonists. Part I: Assessment of toxicity following 30 days of repeated oral dosing of male and female rats with levo-alpha-acetylmethadol HCl (LAAM). Borzelleca, J.F., Egle, J.L., Harris, L.S., Johnson, D.N., Terrill, J.B., Belleville, J.A. Journal of applied toxicology : JAT. (1994)
- Clinical toxicology of drugs used in the treatment of opiate dependency. Fraser, A.D. Clin. Lab. Med. (1990)
- Integration of research in pharmacotherapy for addictive disease: where are we? Where are we going? Ling, W., Shoptaw, S. Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. (1997)
- Enterohepatic circulation of l-alpha-acetylmethadol in the rat. Roerig, D.L., Hasegawa, A.T., Wang, R.I. J. Pharmacol. Exp. Ther. (1980)
- Intravenous and oral l-alpha-acetylmethadol: pharmacodynamics and pharmacokinetics in humans. Walsh, S.L., Johnson, R.E., Cone, E.J., Bigelow, G.E. J. Pharmacol. Exp. Ther. (1998)
- Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. Oda, Y., Kharasch, E.D. J. Pharmacol. Exp. Ther. (2001)
- Transfer of L-alpha-acetylmethadol (LAAM) and L-alpha-acetyl-N-normethadol (norLAAM) by the perfused human placental lobule. Nanovskaya, T.N., Deshmukh, S.V., Miles, R., Burmaster, S., Ahmed, M.S. J. Pharmacol. Exp. Ther. (2003)
- Physiological disposition and biotransformation of l-alpha-[2-3H]acetylmethadol (LAAM) in acutely and chronically treated monkeys. Misra, A.L., Mulé, S.J., Bloch, R., Bates, T.R. J. Pharmacol. Exp. Ther. (1978)
- Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. Oda, Y., Kharasch, E.D. J. Pharmacol. Exp. Ther. (2001)
- Prenatal opiate exposure attenuates LPS-induced fever in adult rats: Role of interleukin-1beta. Hamilton, K.L., Franklin, L.M., Roy, S., Schrott, L.M. Brain Res. (2007)
- Cardiac effects of 1-alpha-acetylmethadol. V. Possible involvement of the autonomic nervous system. Eikenburg, D.C., Stickney, J.L. Toxicol. Appl. Pharmacol. (1979)
- Peripheral sympatholytic effects of 1-alpha-acetylmethadol. Stickney, J.L., Eikenburg, D.C. J. Cardiovasc. Pharmacol. (1981)
- Sex and age dependence of the "selective" induction of rat hepatic microsomal epoxide hydratase following trans-stilbene oxide, l-alpha-acetylmethadol, or phenobarbital treatment. Gontovnick, L.S., Bellward, G.D. Biochem. Pharmacol. (1980)
- Hepatic glutathione and hepatotoxicity: effects of cytochrome P-450 complexing compounds SKF 525-A, L-alpha acetylmethadol (LAAM), norLAAM, and piperonyl butoxide. James, R.C., Harbison, R.D. Biochem. Pharmacol. (1982)
- Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients. Oliveto, A., Poling, J., Sevarino, K.A., Gonsai, K.R., McCance-Katz, E.F., Stine, S.M., Kosten, T.R. Drug and alcohol dependence. (2005)
- Development of cellular tolerance to lethality and analgesia concurrent with physical dependence following repeated oral administration of LAAM. Masten, L.W. Drug and alcohol dependence. (1979)
- Interactions of the narcotic l-alpha-acetylmethadol with human cardiac K+ channels. Kang, J., Chen, X.L., Wang, H., Rampe, D. Eur. J. Pharmacol. (2003)
- Opiate withdrawal in utero increases neonatal morbidity in the rat. Lichtblau, L., Sparber, S.B. Science (1981)
- Methadyl acetate and methadone. An open comparison. Senay, E.C., Dorus, W., Renault, P.F. JAMA (1977)
- Effects of levo-alpha-acetylmethadol (LAAM) on morphine self-administration in the rat. Lukas, S.E., Moreton, J.E., Khazan, N. Psychopharmacology (Berl.) (1981)