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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Roles of urokinase type plasminogen activator in a brain stab wound.

Urokinase type plasminogen activator (uPA) may influence brain pathophysiology after injury. We studied disruption of the blood-brain barrier (BBB) and changes in the vasculature after a brain stab wound in uPA-deficient, uPA receptor-deficient, and PA inhibitor-1 (PAI-1) deficient mice. The extravasation of immunoglobulin was greater in PAI-1 deficient mice; less pronounced in uPA-deficient mice; similar to controls in uPA receptor-deficient mice. Vasculatures in the wound proliferated in PAI-1 deficient mice. Our study shows that uPA affects BBB disruption. PA enhances angiogenesis after brain injury.[1]

References

  1. Roles of urokinase type plasminogen activator in a brain stab wound. Kataoka, K., Asai, T., Taneda, M., Ueshima, S., Matsuo, O., Kuroda, R., Kawabata, A., Carmeliet, P. Brain Res. (2000) [Pubmed]
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