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MeSH Review

Brain Injuries

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Disease relevance of Brain Injuries


Psychiatry related information on Brain Injuries


High impact information on Brain Injuries

  • The glucose-transporter protein and glucopenic brain injury [11].
  • An EP1 receptor inhibitor reduces brain injury when administered 6 hours after MCA occlusion, suggesting that EP1 receptor inhibition may be a viable therapeutic option in ischemic stroke [12].
  • In mice overexpressing human UCP-2, brain damage was diminished after experimental stroke and traumatic brain injury, and neurological recovery was enhanced [13].
  • Hence it is possible that tPA upregulates MMPs in the brain, and that subsequent matrix degradation causes brain injury [14].
  • Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia [2].

Chemical compound and disease context of Brain Injuries


Biological context of Brain Injuries


Anatomical context of Brain Injuries


Gene context of Brain Injuries


Analytical, diagnostic and therapeutic context of Brain Injuries


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  2. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Han, B.H., DeMattos, R.B., Dugan, L.L., Kim-Han, J.S., Brendza, R.P., Fryer, J.D., Kierson, M., Cirrito, J., Quick, K., Harmony, J.A., Aronow, B.J., Holtzman, D.M. Nat. Med. (2001) [Pubmed]
  3. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Faden, A.I., Demediuk, P., Panter, S.S., Vink, R. Science (1989) [Pubmed]
  4. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms. Schmidt, B., Asztalos, E.V., Roberts, R.S., Robertson, C.M., Sauve, R.S., Whitfield, M.F. JAMA (2003) [Pubmed]
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  7. Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury. McAllister, T.W., Rhodes, C.H., Flashman, L.A., McDonald, B.C., Belloni, D., Saykin, A.J. The American journal of psychiatry. (2005) [Pubmed]
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  11. The glucose-transporter protein and glucopenic brain injury. Fishman, R.A. N. Engl. J. Med. (1991) [Pubmed]
  12. Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Kawano, T., Anrather, J., Zhou, P., Park, L., Wang, G., Frys, K.A., Kunz, A., Cho, S., Orio, M., Iadecola, C. Nat. Med. (2006) [Pubmed]
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  14. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Wang, X., Lee, S.R., Arai, K., Lee, S.R., Tsuji, K., Rebeck, G.W., Lo, E.H. Nat. Med. (2003) [Pubmed]
  15. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Woiciechowsky, C., Asadullah, K., Nestler, D., Eberhardt, B., Platzer, C., Schöning, B., Glöckner, F., Lanksch, W.R., Volk, H.D., Döcke, W.D. Nat. Med. (1998) [Pubmed]
  16. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Bruce, A.J., Boling, W., Kindy, M.S., Peschon, J., Kraemer, P.J., Carpenter, M.K., Holtsberg, F.W., Mattson, M.P. Nat. Med. (1996) [Pubmed]
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  18. Lesion-induced sprouting in the rat dentate gyrus is inhibited by repeated ethanol administration. West, J.R., Lind, M.D., Demuth, R.M., Parker, E.S., Alkana, R.L., Cassell, M., Black, A.C. Science (1982) [Pubmed]
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  20. Endocytic pathway alterations in human hippocampus after global ischemia and the influence of APOE genotype. McColl, B.W., Graham, D.I., Weir, C.J., White, F., Horsburgh, K. Am. J. Pathol. (2003) [Pubmed]
  21. Induction of cell death by sera from patients with acute brain injury as a mechanism of production of autoantibodies. López-Escribano, H., Miñambres, E., Labrador, M., Bartolomé, M.J., López-Hoyos, M. Arthritis Rheum. (2002) [Pubmed]
  22. Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats. Clarke, W.E., Berry, M., Smith, C., Kent, A., Logan, A. Mol. Cell. Neurosci. (2001) [Pubmed]
  23. Recovery of impaired endothelium-dependent relaxation after fluid-percussion brain injury in cats. Ellison, M.D., Erb, D.E., Kontos, H.A., Povlishock, J.T. Stroke (1989) [Pubmed]
  24. Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury. Sun, L., Lee, J., Fine, H.A. J. Clin. Invest. (2004) [Pubmed]
  25. FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Yoshimura, S., Takagi, Y., Harada, J., Teramoto, T., Thomas, S.S., Waeber, C., Bakowska, J.C., Breakefield, X.O., Moskowitz, M.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  26. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Brines, M.L., Ghezzi, P., Keenan, S., Agnello, D., de Lanerolle, N.C., Cerami, C., Itri, L.M., Cerami, A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  27. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Iadecola, C., Niwa, K., Nogawa, S., Zhao, X., Nagayama, M., Araki, E., Morham, S., Ross, M.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  28. Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats. Wei, E.P., Kontos, H.A., Dietrich, W.D., Povlishock, J.T., Ellis, E.F. Circ. Res. (1981) [Pubmed]
  29. Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. Leyssen, M., Ayaz, D., Hébert, S.S., Reeve, S., De Strooper, B., Hassan, B.A. EMBO J. (2005) [Pubmed]
  30. Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Celik, M., Gökmen, N., Erbayraktar, S., Akhisaroglu, M., Konakc, S., Ulukus, C., Genc, S., Genc, K., Sagiroglu, E., Cerami, A., Brines, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  31. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Alessandrini, A., Namura, S., Moskowitz, M.A., Bonventre, J.V. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  32. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Dubal, D.B., Zhu, H., Yu, J., Rau, S.W., Shughrue, P.J., Merchenthaler, I., Kindy, M.S., Wise, P.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  33. Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficits. Biegon, A., Fry, P.A., Paden, C.M., Alexandrovich, A., Tsenter, J., Shohami, E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  34. Phenobarbital modifies seizure-related brain injury in the developing brain. Mikati, M.A., Holmes, G.L., Chronopoulos, A., Hyde, P., Thurber, S., Gatt, A., Liu, Z., Werner, S., Stafstrom, C.E. Ann. Neurol. (1994) [Pubmed]
  35. Release of the neuronal glycoprotein ICAM-5 in serum after hypoxic-ischemic injury. Guo, H., Tong, N., Turner, T., Epstein, L.G., McDermott, M.P., Kilgannon, P., Gelbard, H.A. Ann. Neurol. (2000) [Pubmed]
  36. Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Felderhoff-Mueser, U., Sifringer, M., Polley, O., Dzietko, M., Leineweber, B., Mahler, L., Baier, M., Bittigau, P., Obladen, M., Ikonomidou, C., Bührer, C. Ann. Neurol. (2005) [Pubmed]
  37. BAG1 over-expression in brain protects against stroke. Kermer, P., Digicaylioglu, M.H., Kaul, M., Zapata, J.M., Krajewska, M., Stenner-Liewen, F., Takayama, S., Krajewski, S., Lipton, S.A., Reed, J.C. Brain Pathol. (2003) [Pubmed]
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