The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

In vivo on-line detection of no distribution in endotoxin-treated mice by l-band ESR.

The report describes a method for tracing nitric oxide (NO) distribution in endotoxin-treated mice using in vivo low-frequency L-band (1.1 GHz) electron spin resonance spectroscopy (ESR) in combination with extracellular nitric oxide trapping complex consisting of N-methyl-D-glucamine dithiocarbamate and iron (MGD-Fe). An ESR signal characteristic of the MGD-Fe-NO complex was found in the upper abdomen (liver region), lower abdomen and head region of ICR mice. The origin of NO from the L-arginine-NO synthase (NOS) pathway was confirmed using the NOS inhibitor N(G)-monomethyl-L-arginine (NMMA) and isotopic tracing experiments with 15N-labelled L-arginine. Experiments with mice lacking inducible NOS (iNOS) and matched wild type animals were performed using the NO trapping agent diethyldithiocarbamate (DETC). These experiments demonstrated that endotoxin-induced NO generation in the liver tissue of mice occurs via the iNOS isoform of NOS. The described in vivo ESR technique using a "whole body" resonator allows in vivo on-line detection of endogenous NO in mice.[1]


  1. In vivo on-line detection of no distribution in endotoxin-treated mice by l-band ESR. Komarov, A.M. Cell. Mol. Biol. (Noisy-le-grand) (2000) [Pubmed]
WikiGenes - Universities