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MeSH Review

Mice, Inbred ICR

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Disease relevance of Mice, Inbred ICR

  • The persistence and proliferation rate of mouse skin papillomas were studied in HA/ICR mice initiated with 7,12-dimethylbenz(a)anthracene and promoted three times weekly with phorbol myristate acetate [1].
  • Male ICR mice were intratracheally instilled with bleomycin (5 U/kg of body weight) [2].
  • BACKGROUND: To elucidate the molecular mechanism of diabetic nephropathy, a high-density DNA filter array was employed to survey the gene expression profile of streptozotocin-induced diabetic CD-1 (ICR) mouse kidneys [3].
  • The RR- and a thymidine kinase (TK)-deficient mutant of HSV-1 strain KOS could grow in eye tissues of adult ICR mice [4].
  • Reproductive indices and developmental toxicity were evaluated in Swiss/ICR mice chronically exposed to a subanesthetic (0.01 or 0.1 per cent) or an anesthetic (0.5/1.0 per cent) concentration of enflurane [5].

Psychiatry related information on Mice, Inbred ICR


High impact information on Mice, Inbred ICR


Chemical compound and disease context of Mice, Inbred ICR


Biological context of Mice, Inbred ICR

  • A sensitive 32P-postlabeling method enabled us to study the binding of the environmental carcinogens safrole (600 mumol/kg p.o.), 4-aminobiphenyl (800 mumol/kg), and benzo(a)pyrene (200 mumol/kg) to the DNA of various maternal and fetal tissues after administration of test carcinogens to pregnant ICR mice on day 18 of gestation [20].
  • Species and organ specificity of 6-nitrochrysene (6-NC)-induced carcinogenicity and the potential correlation with aryl hydrocarbon hydroxylase (AHH) induction in the target organs were investigated in both sexes of ICR mice and CD rats [21].
  • Arachidonic acid cascade inhibitors modulate phorbol ester-induced oxidative stress in female ICR mouse skin: differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation [22].
  • At 44 wk, the water intake became five times that of the control ICR mice, and the AQP2 mRNA level in these polydipsic mice was only approximately 5% of control [23].
  • It was concluded that under the conditions of the present experiment, chronic administration of enflurane at its maximum tolerated dose did not lead to an increased incidence of neoplasia in Swiss/ICR mice [24].

Anatomical context of Mice, Inbred ICR


Associations of Mice, Inbred ICR with chemical compounds

  • In naive ICR mice a single 60 mg/kg dose of cocaine was found to produce midzonal (zone 2) coagulative necrosis [30].
  • However, when the oxidative microsomal metabolism of ICR mice was induced by phenobarbital or beta-naphthoflavone, the acinar zone affected was dramatically different [30].
  • Four and 2 days prior to p.o. treatment with benzo(a)pyrene, female ICR mice were given (a) CLA in olive oil, (b) linoleic acid in olive oil, or (c) olive oil alone or plus 0.85% saline (control groups) [31].
  • The effect of phorbol myristate acetate on DNA, RNA, and protein synthesis in the epidermis of Ha/ICR mice was also measured [32].
  • Skin tumors were produced in female ICR mice by 90Sr-90Y beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting [33].

Gene context of Mice, Inbred ICR

  • We show here that IL-11 transcription largely depends on AP-1 transcription factors, activities of which are decreased in SAMP6 as well as aged ICR mice [34].
  • These results were obtained using ICR mice that have 2 related renin genes, Ren1 and Ren2 [35].
  • The activity of Ogg1 was not significantly different in the CB; however, in the CP of ICR mice, the activity of Ogg1 was 34% and 31% lower than Balb/c and C57BL/J, respectively [36].
  • Pretreatment with compound 48/80 produced similar degrees of inhibition of SP-induced scratching in mast cell-deficient mice as well as control +/+ and ICR mice [37].
  • We have examined alterations in the hypothalamo-pituitary GH-somatic growth axis and the hypothalamo-pituitary LH-ovarian axis in a line of transgenic ICR mice expressing human GH (hGH) under the influence of the whey acid protein promoter [38].

Analytical, diagnostic and therapeutic context of Mice, Inbred ICR

  • By cDNA cloning and analysis using polymerase chain reaction, we found that there were two TGN38 isoforms in a strain of mouse (ICR), whereas other strains examined (BALB/c, DBA/2, and C57BL/6) had only one TGN38 [39].
  • Parabiosis with normal control ICR mice for 2 weeks decreased the blood glucose level to 260 +/- 51 mg/100 ml (P less than 0.01) and resulted in serum insulin levels of 46.0 +/- 18.0 microU/ml (P less than 0.01) [40].
  • The amount of prostaglandin D2 (PGD2) in ears, determined by radioimmunoassay specific for PGD2, was elevated 3-fold in +/+ and ICR mice at 3 h after irradiation with 500 mJ/cm2 of UVB in comparison with basal level without irradiation [41].
  • Compared to ICR mouse plasma, C57BL/6J mouse plasma contained more LDL and less HDL1, which might contribute to the susceptibility of C57BL/6J and the resistance of ICR mice to the development of aortic fatty streak lesions when challenged with an atherogenic diet [42].
  • In the present study, we examined the effects of microinjections of plasminogen activator inhibitor-1 (PAI-1), tPA or plasmin into the NAc on morphine-induced dopamine release, hyperlocomotion and anti-nociceptive effects in ICR mice [43].


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  13. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Fahey, J.W., Haristoy, X., Dolan, P.M., Kensler, T.W., Scholtus, I., Stephenson, K.K., Talalay, P., Lozniewski, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  14. Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis. Suzuki, H., Aoshiba, K., Yokohori, N., Nagai, A. Cancer Res. (2003) [Pubmed]
  15. Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. Kohno, H., Suzuki, R., Curini, M., Epifano, F., Maltese, F., Gonzales, S.P., Tanaka, T. Int. J. Cancer (2006) [Pubmed]
  16. Efficacy of nikkomycin Z in the treatment of murine histoplasmosis. Graybill, J.R., Najvar, L.K., Bocanegra, R., Hector, R.F., Luther, M.F. Antimicrob. Agents Chemother. (1998) [Pubmed]
  17. Altered organ growth and zinc and copper distribution in endotoxin-treated neonatal mice. Thomas, D.J., Winchurch, R.A. Pediatr. Res. (1991) [Pubmed]
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  19. Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression. Kwon, K.H., Murakami, A., Tanaka, T., Ohigashi, H. Biochem. Pharmacol. (2005) [Pubmed]
  20. 32P-postlabeling assay in mice of transplacental DNA damage induced by the environmental carcinogens safrole, 4-aminobiphenyl, and benzo(a)pyrene. Lu, L.J., Disher, R.M., Reddy, M.V., Randerath, K. Cancer Res. (1986) [Pubmed]
  21. Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species. Imaida, K., Uneyama, C., Ogasawara, H., Hayashi, S., Fukuhara, K., Miyata, N., Takahashi, M. Cancer Res. (1992) [Pubmed]
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  25. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. Chen, Y.T., Kung, J.T. J. Immunol. (2005) [Pubmed]
  26. The macrophage scavenger receptor type A directs modified proteins to antigen presentation. Nicoletti, A., Caligiuri, G., Törnberg, I., Kodama, T., Stemme, S., Hansson, G.K. Eur. J. Immunol. (1999) [Pubmed]
  27. Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice. Aoki, T., Narita, M., Shibasaki, M., Suzuki, T. Eur. J. Neurosci. (2004) [Pubmed]
  28. Individual differences in a functional organization of the hematopoietic tissue. Necas, E., Znojil, V., Sefc, L., Jirásková, Z. Exp. Hematol. (1989) [Pubmed]
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  32. Effect of phorbol myristate acetate on cyclic nucleotide levels in mouse epidermis. Belman, S., Troll, W., Garte, S.J. Cancer Res. (1978) [Pubmed]
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  34. Decreased AP-1 activity and interleukin-11 expression by bone marrow stromal cells may be associated with impaired bone formation in aged mice. Tohjima, E., Inoue, D., Yamamoto, N., Kido, S., Ito, Y., Kato, S., Takeuchi, Y., Fukumoto, S., Matsumoto, T. J. Bone Miner. Res. (2003) [Pubmed]
  35. Pregnancy-induced changes in renin gene expression in mice. Xia, Y., Wen, H., Prashner, H.R., Chen, R., Inagami, T., Catanzaro, D.F., Kellems, R.E. Biol. Reprod. (2002) [Pubmed]
  36. Strain-specific differences in the expression and activity of Ogg1 in the CNS. Mosquera, D.I., Stedeford, T., Cardozo-Pelaez, F., Sanchez-Ramos, J. Gene Expr. (2003) [Pubmed]
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