Gene Review:
Nos2 - nitric oxide synthase 2, inducible
Mus musculus
Synonyms:
Inducible NO synthase, Inducible NOS, Inosl, MAC-NOS, Macrophage NOS, ...
Moors,
Brune,
Choe,
Xiong,
Ali,
Chen,
Olleros,
Honko,
Unkeless,
West,
Ha,
Bae,
Thomas,
Zhu,
Rehse,
Smith,
Görig,
Ryffel,
Vesin,
Ashizawa,
Plevy,
Chvatchko,
Guler,
Mayer,
Li,
Garcia,
Gühring,
Ates,
Martin,
Ozato,
Baik,
Yim,
Mizel,
Pahl,
Jacobs,
Jankovic,
Coste,
Zeilhofer,
Vassalli,
Itzhak,
Shin,
Jung,
- Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Scott, D.J., Hull, M.A., Cartwright, E.J., Lam, W.K., Tisbury, A., Poulsom, R., Markham, A.F., Bonifer, C., Coletta, P.L. Gastroenterology (2001)
- Lethal Mycobacterium bovis Bacillus Calmette Guérin infection in nitric oxide synthase 2-deficient mice: cell-mediated immunity requires nitric oxide synthase 2. Garcia, I., Guler, R., Vesin, D., Olleros, M.L., Vassalli, P., Chvatchko, Y., Jacobs, M., Ryffel, B. Lab. Invest. (2000)
- The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Guo, Y., Jones, W.K., Xuan, Y.T., Tang, X.L., Bao, W., Wu, W.J., Han, H., Laubach, V.E., Ping, P., Yang, Z., Qiu, Y., Bolli, R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Di Marco, S., Mazroui, R., Dallaire, P., Chittur, S., Tenenbaum, S.A., Radzioch, D., Marette, A., Gallouzi, I.E. Mol. Cell. Biol. (2005)
- Exogenous nitric oxide regulates IFN-gamma plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages. Sheffler, L.A., Wink, D.A., Melillo, G., Cox, G.W. J. Immunol. (1995)
- Phagocytosis is regulated by nitric oxide in murine microglia. Kopec, K.K., Carroll, R.T. Nitric Oxide (2000)
- Expression of inducible nitric oxide synthase in the brains of scrapie-infected mice. Ju, W.K., Park, K.J., Choi, E.K., Kim, J., Carp, R.I., Wisniewski, H.M., Kim, Y.S. J. Neurovirol. (1998)
- Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice. Itzhak, Y., Martin, J.L., Ali, S.F. Synapse (1999)
- Minocycline in Huntington's disease: a pilot study. Thomas, M., Ashizawa, T., Jankovic, J. Mov. Disord. (2004)
- Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. MacMicking, J.D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D.S., Trumbauer, M., Stevens, K., Xie, Q.W., Sokol, K., Hutchinson, N. Cell (1995)
- Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Perreault, M., Marette, A. Nat. Med. (2001)
- Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Zell, J.A., Ignatenko, N.A., Yerushalmi, H.F., Ziogas, A., Besselsen, D.G., Gerner, E.W., Anton-Culver, H. Int. J. Cancer (2007)
- Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. Gühring, H., Görig, M., Ates, M., Coste, O., Zeilhofer, H.U., Pahl, A., Rehse, K., Brune, K. J. Neurosci. (2000)
- Increased mortality, blunted production of nitric oxide, and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic mice. Vodovotz, Y., Kopp, J.B., Takeguchi, H., Shrivastav, S., Coffin, D., Lucia, M.S., Mitchell, J.B., Webber, R., Letterio, J., Wink, D., Roberts, A.B. J. Leukoc. Biol. (1998)
- Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis. Sahrbacher, U.C., Lechner, F., Eugster, H.P., Frei, K., Lassmann, H., Fontana, A. Eur. J. Immunol. (1998)
- Differential expression of nitric oxide synthases in bacterial meningitis: role of the inducible isoform for blood-brain barrier breakdown. Winkler, F., Koedel, U., Kastenbauer, S., Pfister, H.W. J. Infect. Dis. (2001)
- Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes. Gonzalez, C., Cuvellier, S., Hue-Beauvais, C., Lévi-Strauss, M. Diabetologia (2003)
- The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis. Yerushalmi, H.F., Besselsen, D.G., Ignatenko, N.A., Blohm-Mangone, K.A., Padilla-Torres, J.L., Stringer, D.E., Cui, H., Holubec, H., Payne, C.M., Gerner, E.W. Mol. Carcinog. (2006)
- Troglitazone regulates peroxisome proliferator-activated receptors and inducible nitric oxide synthase in murine ovarian macrophages. Minge, C.E., Ryan, N.K., Van Der Hoek, K.H., Robker, R.L., Norman, R.J. Biol. Reprod. (2006)
- Inducible and endothelial nitric oxide synthase: genetic background affects ovulation in mice. Hefler, L.A., Gregg, A.R. Fertil. Steril. (2002)
- Activation of the nitric oxide synthase 2 pathway in the response of bone marrow stromal cells to high doses of ionizing radiation. Gorbunov, N.V., Pogue-Geile, K.L., Epperly, M.W., Bigbee, W.L., Draviam, R., Day, B.W., Wald, N., Watkins, S.C., Greenberger, J.S. Radiat. Res. (2000)
- Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS. Hewett, S.J., Csernansky, C.A., Choi, D.W. Neuron (1994)
- NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Hatano, E., Bennett, B.L., Manning, A.M., Qian, T., Lemasters, J.J., Brenner, D.A. Gastroenterology (2001)
- Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Sebastiani, G., Blais, V., Sancho, V., Vogel, S.N., Stevenson, M.M., Gros, P., Lapointe, J.M., Rivest, S., Malo, D. Infect. Immun. (2002)
- Fluoxetine increases the nitric oxide production via nuclear factor kappa B-mediated pathway in BV2 murine microglial cells. Ha, E., Jung, K.H., Choe, B.K., Bae, J.H., Shin, D.H., Yim, S.V., Baik, H.H. Neurosci. Lett. (2006)
- Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. Guo, H., Mi, Z., Kuo, P.C. J. Biol. Chem. (2008)
- Complex formation of the interferon (IFN) consensus sequence-binding protein with IRF-1 is essential for murine macrophage IFN-gamma-induced iNOS gene expression. Xiong, H., Zhu, C., Li, H., Chen, F., Mayer, L., Ozato, K., Unkeless, J.C., Plevy, S.E. J. Biol. Chem. (2003)
- Regulation of cytokine-induced iNOS expression by a hairpin oligonucleotide in murine cerebral endothelial cells. Xu, J., Wu, Y., He, L., Yang, Y., Moore, S.A., Hsu, C.Y. Biochem. Biophys. Res. Commun. (1997)
- Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression through the activation of p38 kinase in murine macrophages. Lee, K.Y., You, H.J., Jeong, H.G., Kang, J.S., Kim, H.M., Rhee, S.D., Jeon, Y.J. Int. Immunopharmacol. (2004)
- Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase. Minamoto, K., Harada, H., Lama, V.N., Fedarau, M.A., Pinsky, D.J. J. Exp. Med. (2005)
- Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression. Fritsche, G., Dlaska, M., Barton, H., Theurl, I., Garimorth, K., Weiss, G. J. Immunol. (2003)
- Roles of tyrosine kinases in the regulation of nitric oxide synthesis in murine liver cells: modulation of NF-kappa B activity by tyrosine kinases. Lee, B.S., Kang, H.S., Pyun, K.H., Choi, I. Hepatology (1997)
- Role of interferon regulatory factor-1 in double-stranded RNA-induced iNOS expression by mouse islets. Blair, L.A., Maggi, L.B., Scarim, A.L., Corbett, J.A. J. Biol. Chem. (2002)
- Regulatory effects of iNOS on acute lung inflammatory responses in mice. Speyer, C.L., Neff, T.A., Warner, R.L., Guo, R.F., Sarma, J.V., Riedemann, N.C., Murphy, M.E., Murphy, H.S., Ward, P.A. Am. J. Pathol. (2003)
- Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. Mizel, S.B., Honko, A.N., Moors, M.A., Smith, P.S., West, A.P. J. Immunol. (2003)
- Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. Carrera, L., Gazzinelli, R.T., Badolato, R., Hieny, S., Muller, W., Kuhn, R., Sacks, D.L. J. Exp. Med. (1996)
- Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. Räisänen-Sokolowski, A., Mottram, P.L., Glysing-Jensen, T., Satoskar, A., Russell, M.E. J. Clin. Invest. (1997)
- Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Fukumura, D., Gohongi, T., Kadambi, A., Izumi, Y., Ang, J., Yun, C.O., Buerk, D.G., Huang, P.L., Jain, R.K. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha. Murakami, A., Kawabata, K., Koshiba, T., Gao, G., Nakamura, Y., Koshimizu, K., Ohigashi, H. Cancer Res. (2000)
- In vivo regulation of inducible no synthase in immune-mediated liver injury in mice. Koerber, K., Sass, G., Kiemer, A.K., Vollmar, A.M., Tiegs, G. Hepatology (2002)