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Chemical Compound Review

meglumine     (2R,3R,4R,5S)-6- methylaminohexane-1,2,3,4...

Synonyms: Meglumin, Meglumina, Glucantime, Megluminum, Methylglucamin, ...
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Disease relevance of meglumine


Psychiatry related information on meglumine


High impact information on meglumine


Chemical compound and disease context of meglumine


Biological context of meglumine

  • The replacement of external N-methyl-D-glucamine with K+, but not other monovalent ions (choline, Li+), decreased the potency of Mg2+ as an inhibitor of Na+/Ca2+ antiport 6.7-fold [18].
  • Replacement of sodium with potassium or N-methyl-D-glucamine in NG108-15 membrane or intact cell suspensions also resulted in an increase in [3H]etorphine binding, but in these cells the effect was associated with an increase in the number of binding sites measurable under these experimental conditions [19].
  • The membrane-impermeable metal chelator, N-methyl-D-glucamine dithiocarbamate (MGD; 200 microM), in the presence of DNIC significantly increased apoptosis, but had no effect on its own [20].
  • Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate [21].
  • These channels had a mean conductance of 20 pS, were impermeable to NMDG, and their mean open probability increased at positive membrane potentials [22].

Anatomical context of meglumine


Associations of meglumine with other chemical compounds


Gene context of meglumine

  • The large cation N-methyl-D-glucamine, which does not permeate NMDA receptor channels, enhanced 3-OH-GA-induced Ca(2+) increase and cell damage [33].
  • We measured the contributions of Ca(2+) clearance components by inhibiting SERCA2 (with 10 microM cyclopiazonic acid) and/or NCX (by replacing NaCl with N-methyl-D-glucamine/HCl plus 10 microM KB-R7943) [34].
  • The CCK-8-induced cation currents were antagonized by PD135,158 (4-¿[2-[[3-(1H-indol-3yl)-2-mehtyl-1-oxo-2-[[[1.7.7.-trimeth yl-bicyclo [2.2.1]hept-2-yl)oxy]carbonyl]amino]propyl]amino]-1-phenylethyl]amino-4- oxo- [1S-1 alpha, 2 beta [S*(S*)]4 alpha]¿-butanoate N-methyl-D-glucamine), a highly specific and potent CCKB receptor antagonist [35].
  • The permeability to NMDG developed as quickly as the channel opened, in contrast to the P2X7 receptor where the NMDG permeability develops over several seconds [36].
  • The following treatments were tested alone or in combination: sulfated CCK-8 (CCK-8s, 0.5-1 microg), PD 135158 (N-methyl-D-glucamine, 0.1 microg), a CCK-2 receptor antagonist, lorglumide (0.1-0.3 microg), a CCK-1 receptor antagonist [37].

Analytical, diagnostic and therapeutic context of meglumine


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  3. Treatment of visceral leishmaniasis in HIV-infected patients: a randomized trial comparing meglumine antimoniate with amphotericin B. Spanish HIV-Leishmania Study Group. Laguna, F., López-Vélez, R., Pulido, F., Salas, A., Torre-Cisneros, J., Torres, E., Medrano, F.J., Sanz, J., Picó, G., Gómez-Rodrigo, J., Pasquau, J., Alvar, J. AIDS (1999) [Pubmed]
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  9. The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways. Mall, M., Bleich, M., Greger, R., Schreiber, R., Kunzelmann, K. J. Clin. Invest. (1998) [Pubmed]
  10. Immunotherapy versus chemotherapy in localised cutaneous leishmaniasis. Convit, J., Castellanos, P.L., Rondon, A., Pinardi, M.E., Ulrich, M., Castes, M., Bloom, B., Garcia, L. Lancet (1987) [Pubmed]
  11. Regulation of the P2X7 receptor permeability to large molecules by extracellular Cl- and Na+. Li, Q., Luo, X., Muallem, S. J. Biol. Chem. (2005) [Pubmed]
  12. 20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells. Basora, N., Boulay, G., Bilodeau, L., Rousseau, E., Payet, M.D. J. Biol. Chem. (2003) [Pubmed]
  13. Characterization of the antimonial antileishmanial agent meglumine antimonate (glucantime). Roberts, W.L., McMurray, W.J., Rainey, P.M. Antimicrob. Agents Chemother. (1998) [Pubmed]
  14. Infarcted myocardium in pigs: MR imaging enhanced with slow-interstitial-diffusion gadolinium compound P760. Kroft, L.J., Doornbos, J., van der Geest, R.J., Benderbous, S., de Roos, A. Radiology. (1999) [Pubmed]
  15. Renal tolerance for ioxaglate in patients with chronic renal failure. Deray, G., Cacoub, P., Jacquiaud, C., Drobinski, G., Brillet, G., Bunker, D., Jaudon, M.C., Jacobs, C., Drobinski, M. Radiology. (1991) [Pubmed]
  16. The in-vitro anti-leishmanial activity of inhibitors of ergosterol biosynthesis. Gebre-Hiwot, A., Frommel, D. J. Antimicrob. Chemother. (1993) [Pubmed]
  17. Efficacy of aminosidine administered alone or in combination with meglumine antimoniate for the treatment of experimental visceral leishmaniasis caused by Leishmania infantum. Gangneux, J.P., Sulahian, A., Garin, Y.J., Derouin, F. J. Antimicrob. Chemother. (1997) [Pubmed]
  18. Na+/Ca2+ antiport in cultured arterial smooth muscle cells. Inhibition by magnesium and other divalent cations. Smith, J.B., Cragoe, E.J., Smith, L. J. Biol. Chem. (1987) [Pubmed]
  19. Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes. Puttfarcken, P., Werling, L.L., Brown, S.R., Cote, T.E., Cox, B.M. Mol. Pharmacol. (1986) [Pubmed]
  20. Dinitrosyl-iron triggers apoptosis in Jurkat cells despite overexpression of Bcl-2. Kleschyov, A.L., Strand, S., Schmitt, S., Gottfried, D., Skatchkov, M., Sjakste, N., Daiber, A., Umansky, V., Munzel, T. Free Radic. Biol. Med. (2006) [Pubmed]
  21. Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate. Cruz, A., Rainey, P.M., Herwaldt, B.L., Stagni, G., Palacios, R., Trujillo, R., Saravia, N.G. J. Infect. Dis. (2007) [Pubmed]
  22. A non-selective cation current activated via the multifunctional Ca(2+)-calmodulin-dependent protein kinase in human epithelial cells. Braun, A.P., Schulman, H. J. Physiol. (Lond.) (1995) [Pubmed]
  23. Comparative neurotoxicity of angiographic contrast media. Velaj, R., Drayer, B., Albright, R., Fram, E. Neurology (1985) [Pubmed]
  24. MR guidance of targeted injections into border and core of scarred myocardium in pigs. Saeed, M., Martin, A.J., Lee, R.J., Weber, O., Revel, D., Saloner, D., Higgins, C.B. Radiology. (2006) [Pubmed]
  25. Long-term induction of a unique C1- current by endothelin-1 in an epithelial cell line from rat lung: evidence for regulation of cytoplasmic calcium. Mair, N., Frick, M., Meraner, A., Schramek, H., Dietl, P. J. Physiol. (Lond.) (1998) [Pubmed]
  26. Renal ablation using hot contrast medium: an experimental study. Work in progress. Cragg, A.H., Rosel, P., Rysavy, J.A., Rholl, K.S., Bendel, W., Vlodaver, Z., Castaneda-Zuniga, W.R., Amplatz, K. Radiology. (1983) [Pubmed]
  27. Open-channel block by internally applied amines inhibits activation gate closure in batrachotoxin-activated sodium channels. Zamponi, G.W., French, R.J. Biophys. J. (1994) [Pubmed]
  28. Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes. Nuttle, L.C., Dubyak, G.R. J. Biol. Chem. (1994) [Pubmed]
  29. Detailed methods for the quantification of nitric oxide in aqueous solutions using either an oxygen monitor or EPR. Venkataraman, S., Martin, S.M., Schafer, F.Q., Buettner, G.R. Free Radic. Biol. Med. (2000) [Pubmed]
  30. Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-D-glucamine dithiocarbamate. Lu, C., Koppenol, W.H. Free Radic. Biol. Med. (2005) [Pubmed]
  31. Ion permeation through 5-hydroxytryptamine-gated channels in neuroblastoma N18 cells. Yang, J. J. Gen. Physiol. (1990) [Pubmed]
  32. Knee arthrography: a comparison of iohexol, ioxaglate sodium meglumine, and metrizoate. Obermann, W.R., Kieft, G.J. Radiology. (1987) [Pubmed]
  33. Ca(2+) and Na(+) dependence of 3-hydroxyglutarate-induced excitotoxicity in primary neuronal cultures from chick embryo telencephalons. Kölker, S., Köhr, G., Ahlemeyer, B., Okun, J.G., Pawlak, V., Hörster, F., Mayatepek, E., Krieglstein, J., Hoffmann, G.F. Pediatr. Res. (2002) [Pubmed]
  34. Role of plasma membrane Ca2+-ATPase in contraction-relaxation processes of the bladder: evidence from PMCA gene-ablated mice. Liu, L., Ishida, Y., Okunade, G., Shull, G.E., Paul, R.J. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  35. The excitatory effect of cholecystokinin on rat neostriatal neurons: ionic and molecular mechanisms. Wu, T., Wang, H.L. Eur. J. Pharmacol. (1996) [Pubmed]
  36. Pharmacological and biophysical properties of the human P2X5 receptor. Bo, X., Jiang, L.H., Wilson, H.L., Kim, M., Burnstock, G., Surprenant, A., North, R.A. Mol. Pharmacol. (2003) [Pubmed]
  37. Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray. Netto, C.F., Guimarães, F.S. Neuropsychopharmacology (2004) [Pubmed]
  38. Angiotensin II stimulates macula densa basolateral sodium/hydrogen exchange via type 1 angiotensin II receptors. Bell, P.D., Peti-Peterdi, J. J. Am. Soc. Nephrol. (1999) [Pubmed]
  39. Measurement of S-nitrosothiols in extracellular fluids from healthy human volunteers and rheumatoid arthritis patients, using electron paramagnetic resonance spectrometry. Rocks, S.A., Davies, C.A., Hicks, S.L., Webb, A.J., Klocke, R., Timmins, G.S., Johnston, A., Jawad, A.S., Blake, D.R., Benjamin, N., Winyard, P.G. Free Radic. Biol. Med. (2005) [Pubmed]
  40. Retention of antimony in skin biopsies of leishmaniasis patients after treatment with N-methylglucamine antimoniate. Dorea, J.G., Merchan-Hamann, E., Ryan, D.E., Holzbecher, J. Clin. Chem. (1990) [Pubmed]
  41. Ionized calcium levels in coronary sinus blood during coronary angiography: effects of four contrast media. Mitsumori, M., Hayakawa, K., Torizuka, T., Okuno, Y., Monji, T., Uwatoko, H., Kitamura, K., Abe, M. Radiology. (1992) [Pubmed]
  42. Biliary tract depiction in living potential liver donors: comparison of conventional MR, mangafodipir trisodium-enhanced excretory MR, and multi-detector row CT cholangiography--initial experience. Yeh, B.M., Breiman, R.S., Taouli, B., Qayyum, A., Roberts, J.P., Coakley, F.V. Radiology. (2004) [Pubmed]
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