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Chemical Compound Review

meglumine     (2R,3R,4R,5S)-6- methylaminohexane-1,2,3,4...

Synonyms: Meglumin, Meglumina, Glucantime, Megluminum, Methylglucamin, ...
 
 
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Disease relevance of meglumine

 

Psychiatry related information on meglumine

 

High impact information on meglumine

 

Chemical compound and disease context of meglumine

 

Biological context of meglumine

  • The replacement of external N-methyl-D-glucamine with K+, but not other monovalent ions (choline, Li+), decreased the potency of Mg2+ as an inhibitor of Na+/Ca2+ antiport 6.7-fold [18].
  • Replacement of sodium with potassium or N-methyl-D-glucamine in NG108-15 membrane or intact cell suspensions also resulted in an increase in [3H]etorphine binding, but in these cells the effect was associated with an increase in the number of binding sites measurable under these experimental conditions [19].
  • The membrane-impermeable metal chelator, N-methyl-D-glucamine dithiocarbamate (MGD; 200 microM), in the presence of DNIC significantly increased apoptosis, but had no effect on its own [20].
  • Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate [21].
  • These channels had a mean conductance of 20 pS, were impermeable to NMDG, and their mean open probability increased at positive membrane potentials [22].
 

Anatomical context of meglumine

 

Associations of meglumine with other chemical compounds

 

Gene context of meglumine

  • The large cation N-methyl-D-glucamine, which does not permeate NMDA receptor channels, enhanced 3-OH-GA-induced Ca(2+) increase and cell damage [33].
  • We measured the contributions of Ca(2+) clearance components by inhibiting SERCA2 (with 10 microM cyclopiazonic acid) and/or NCX (by replacing NaCl with N-methyl-D-glucamine/HCl plus 10 microM KB-R7943) [34].
  • The CCK-8-induced cation currents were antagonized by PD135,158 (4-¿[2-[[3-(1H-indol-3yl)-2-mehtyl-1-oxo-2-[[[1.7.7.-trimeth yl-bicyclo [2.2.1]hept-2-yl)oxy]carbonyl]amino]propyl]amino]-1-phenylethyl]amino-4- oxo- [1S-1 alpha, 2 beta [S*(S*)]4 alpha]¿-butanoate N-methyl-D-glucamine), a highly specific and potent CCKB receptor antagonist [35].
  • The permeability to NMDG developed as quickly as the channel opened, in contrast to the P2X7 receptor where the NMDG permeability develops over several seconds [36].
  • The following treatments were tested alone or in combination: sulfated CCK-8 (CCK-8s, 0.5-1 microg), PD 135158 (N-methyl-D-glucamine, 0.1 microg), a CCK-2 receptor antagonist, lorglumide (0.1-0.3 microg), a CCK-1 receptor antagonist [37].
 

Analytical, diagnostic and therapeutic context of meglumine

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