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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An orphaned mammalian beta-globin gene of ancient evolutionary origin.

Mammals possess multiple, closely linked beta-globin genes that differ in the timing of their expression during development. These genes have been thought to be derived from a single ancestral gene, by duplication events that occurred after the separation of the mammals and birds. We report the isolation and characterization of an atypical beta-like globin gene (omega-globin) in marsupials that appears to be more closely related to avian beta-globin genes than to other mammalian beta-globin genes, including those previously identified in marsupials. Phylogenetic analyses indicate that omega-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds. Furthermore, we show that omega-globin is unlinked to the previously characterized beta-globin gene cluster of marsupials, making this the first report of an orphaned beta-like globin gene expressed in a vertebrate.[1]

References

  1. An orphaned mammalian beta-globin gene of ancient evolutionary origin. Wheeler, D., Hope, R., Cooper, S.B., Dolman, G., Webb, G.C., Bottema, C.D., Gooley, A.A., Goodman, M., Holland, R.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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