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Disease relevance of Marsupialia


High impact information on Marsupialia

  • Marsupial RBM1 is closely related to human RBM1, but, like the related autosomal gene hnRNPG, lacks the amplification of an exon [6].
  • Widespread expression of the testis-determining gene SRY in a marsupial [7].
  • Marsupials, placentals and their close therian relatives possess complex (tribosphenic) molars that are capable of versatile occlusal functions [8].
  • We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species [9].
  • This implies ZFY is not the primary sex-determining gene in marsupials [10].

Chemical compound and disease context of Marsupialia


Biological context of Marsupialia


Anatomical context of Marsupialia


Associations of Marsupialia with chemical compounds

  • Phenypressin (Phe2-Arg8-vasopressin), a new neurohypophysial peptide found in marsupials [21].
  • The opossum, Monodelphis domestica, was used because cells of these marsupials have an enzyme that is activated by visible light (photoreactivating enzyme) and repairs ultraviolet radiation (UVR)-induced pyrimidine dimers in DNA [22].
  • In contrast to most vertebrate species that possess one oxytocin-like hormone and one vasopressin-like hormone, a few groups, such as marsupials or cartilaginous fishes, are endowed with two peptides of either or both types, suggesting possible gene duplications [23].
  • Prostate formation in a marsupial is mediated by the testicular androgen 5 alpha-androstane-3 alpha,17 beta-diol [24].
  • Given that the interphotoreceptor retinoid binding protein gene is a single-copy gene that functions in the visual cycle and that the marsupial mole is blind with degenerate eyes, this finding suggests that phenotypic degeneration of the eyes is accompanied by parallel changes at the molecular level as a result of relaxed selective constraints [25].

Gene context of Marsupialia

  • The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination [14].
  • SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans [26].
  • Smcy is well conserved on the Y in mouse, man and even marsupials [27].
  • The autosomal localization of marsupial homologues of human PAR1 genes and their co-localization with human Xp22 genes implies that the human PAR1 represents a relic of part of an autosomal region added to both X and Y chromosomes between 80 and 130 MYrBP [28].
  • Previous studies revealed that Igf2 and Mpr/Igf2r are imprinted in eutherian mammals and marsupials but not in monotremes or birds [29].

Analytical, diagnostic and therapeutic context of Marsupialia


  1. Photoreactivation of UV-induced pyrimidine dimers and erythema in the marsupial Monodelphis domestica. Ley, R.D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  2. "Marsupial cava" and ruptured abdominal aortic aneurysm. A case report and review of the literature. Schiavetta, A., Cerruti, R., Cantello, C., Patrone, P. J. Vasc. Surg. (1998) [Pubmed]
  3. Developmental expression of the androgen receptor during virilization of the urogenital system of a marsupial. Butler, C.M., Harry, J.L., Deakin, J.E., Cooper, D.W., Renfree, M.B. Biol. Reprod. (1998) [Pubmed]
  4. Photorepair of ultraviolet radiation-induced pyrimidine dimers in corneal DNA. Ley, R.D., Applegate, L.A., Freeman, S.E. Mutat. Res. (1988) [Pubmed]
  5. Borrelia-like spirochetes recovered from ticks and small mammals collected in the Atlantic Forest Reserve, Cotia county, State of São Paulo, Brazil. Abel, I.S., Marzagão, G., Yoshinari, N.H., Schumaker, T.T. Mem. Inst. Oswaldo Cruz (2000) [Pubmed]
  6. A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome. Delbridge, M.L., Harry, J.L., Toder, R., O'Neill, R.J., Ma, K., Chandley, A.C., Graves, J.A. Nat. Genet. (1997) [Pubmed]
  7. Widespread expression of the testis-determining gene SRY in a marsupial. Harry, J.L., Koopman, P., Brennan, F.E., Graves, J.A., Renfree, M.B. Nat. Genet. (1995) [Pubmed]
  8. Dual origin of tribosphenic mammals. Luo, Z.X., Cifelli, R.L., Kielan-Jaworowska, Z. Nature (2001) [Pubmed]
  9. Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials. Foster, J.W., Brennan, F.E., Hampikian, G.K., Goodfellow, P.N., Sinclair, A.H., Lovell-Badge, R., Selwood, L., Renfree, M.B., Cooper, D.W., Graves, J.A. Nature (1992) [Pubmed]
  10. Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials. Sinclair, A.H., Foster, J.W., Spencer, J.A., Page, D.C., Palmer, M., Goodfellow, P.N., Graves, J.A. Nature (1988) [Pubmed]
  11. The acute phase response of plasma proteins in the polyprotodont marsupial Monodelphis domestica. Richardson, S.J., Dziegielewska, K.M., Andersen, N.A., Frost, S., Schreiber, G. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1998) [Pubmed]
  12. Protection after x-irradiation by 1,4-dithiothreitol of two mammalian cell types in vitro. Bick, Y.A., Brown, J.K. Cytobios (1979) [Pubmed]
  13. Cloning and chromosomal location of the alpha- and beta-globin genes from a marsupial. Wainwright, B., Hope, R. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  14. The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination. Pask, A., Renfree, M.B., Marshall Graves, J.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  15. An orphaned mammalian beta-globin gene of ancient evolutionary origin. Wheeler, D., Hope, R., Cooper, S.B., Dolman, G., Webb, G.C., Bottema, C.D., Gooley, A.A., Goodman, M., Holland, R.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  16. An SRY-related sequence on the marsupial X chromosome: implications for the evolution of the mammalian testis-determining gene. Foster, J.W., Graves, J.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. Posttranslational modifications of alpha tubulin: detyrosination and acetylation differentiate populations of interphase microtubules in cultured cells. Bulinski, J.C., Richards, J.E., Piperno, G. J. Cell Biol. (1988) [Pubmed]
  18. Purification of a high molecular weight actin filament gelation protein from Acanthamoeba that shares antigenic determinants with vertebrate spectrins. Pollard, T.D. J. Cell Biol. (1984) [Pubmed]
  19. Evidence for import of a lysyl-tRNA into marsupial mitochondria. Dörner, M., Altmann, M., Pääbo, S., Mörl, M. Mol. Biol. Cell (2001) [Pubmed]
  20. Molecular characterization and in-vitro hormonal requirements for expression of two casein genes from a marsupial. Collet, C., Joseph, R., Nicholas, K. J. Mol. Endocrinol. (1992) [Pubmed]
  21. Phenypressin (Phe2-Arg8-vasopressin), a new neurohypophysial peptide found in marsupials. Chauvet, M.T., Hurpet, D., Chauvet, J., Acher, R. Nature (1980) [Pubmed]
  22. Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation. Applegate, L.A., Ley, R.D., Alcalay, J., Kripke, M.L. J. Exp. Med. (1989) [Pubmed]
  23. Special evolution of neurohypophysial hormones in cartilaginous fishes: asvatocin and phasvatocin, two oxytocin-like peptides isolated from the spotted dogfish (Scyliorhinus caniculus). Chauvet, J., Rouille, Y., Chauveau, C., Chauvet, M.T., Acher, R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  24. Prostate formation in a marsupial is mediated by the testicular androgen 5 alpha-androstane-3 alpha,17 beta-diol. Shaw, G., Renfree, M.B., Leihy, M.W., Shackleton, C.H., Roitman, E., Wilson, J.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  25. The interphotoreceptor retinoid binding protein gene in therian mammals: implications for higher level relationships and evidence for loss of function in the marsupial mole. Springer, M.S., Burk, A., Kavanagh, J.R., Waddell, V.G., Stanhope, M.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  26. Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. D'Esposito, M., Matarazzo, M.R., Ciccodicola, A., Strazzullo, M., Mazzarella, R., Quaderi, N.A., Fujiwara, H., Ko, M.S., Rowe, L.B., Ricco, A., Archidiacono, N., Rocchi, M., Schlessinger, D., D'Urso, M. Hum. Mol. Genet. (1997) [Pubmed]
  27. A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens. Agulnik, A.I., Mitchell, M.J., Lerner, J.L., Woods, D.R., Bishop, C.E. Hum. Mol. Genet. (1994) [Pubmed]
  28. The origin and evolution of the pseudoautosomal regions of human sex chromosomes. Graves, J.A., Wakefield, M.J., Toder, R. Hum. Mol. Genet. (1998) [Pubmed]
  29. Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region. Yokomine, T., Shirohzu, H., Purbowasito, W., Toyoda, A., Iwama, H., Ikeo, K., Hori, T., Mizuno, S., Tsudzuki, M., Matsuda, Y., Hattori, M., Sakaki, Y., Sasaki, H. Genome Res. (2005) [Pubmed]
  30. Fast evolution of interleukin-2 in mammals and positive selection in ruminants. Zelus, D., Robinson-Rechavi, M., Delacre, M., Auriault, C., Laudet, V. J. Mol. Evol. (2000) [Pubmed]
  31. The effect of intravenous infusion of angiotensin II on drinking in the Australian marsupial Trichosurus vulpecula. Young, C.E., McDonald, I.R. J. Physiol. (Lond.) (1978) [Pubmed]
  32. Serotonergic neurons in the brainstem of the wallaby, Macropus eugenii. Ferguson, I.A., Hardman, C.D., Marotte, L.R., Salardini, A., Halasz, P., Vu, D., Waite, P.M. J. Comp. Neurol. (1999) [Pubmed]
  33. Localization of G6PD and HPRT to different arms of the X chromosome of the North American marsupial (Didelphis virginiana) by in situ hybridization and deletion mapping: evolutionary significance. Driscoll, D.J., Migeon, B.R. Genomics (1988) [Pubmed]
  34. The evolution of mammalian sex chromosomes and the origin of sex determining genes. Graves, J.A. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1995) [Pubmed]
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