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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Disposition and metabolism of the flavonoid chrysin in normal volunteers.

AIMS: To describe the oral disposition of the dietary flavonoid chrysin in healthy volunteers. METHODS: Oral 400 mg doses of chrysin were administered to seven subjects. Chrysin and metabolites were assayed in plasma, urine and faeces by h.p.l.c. RESULTS: Peak plasma chrysin concentrations were only 3-16 ng ml(-1) with AUCs of 5-193 ng ml(-1) h. Plasma chrysin sulphate concentrations were 30-fold higher (AUC 450-4220 ng ml(-1) h). In urine, chrysin and chrysin glucuronide accounted for 0.2-3.1 mg and 2-26 mg, respectively. Most of the dose appeared in faeces as chrysin. Parallel experiments in rats showed high bile concentrations of chrysin conjugates. CONCLUSIONS: These findings, together with previous data using Caco-2 cells, suggest that chrysin has low oral bioavailability, mainly due to extensive metabolism and efflux of metabolites back into the intestine for hydrolysis and faecal elimination.[1]

References

  1. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Walle, T., Otake, Y., Brubaker, J.A., Walle, U.K., Halushka, P.V. British journal of clinical pharmacology. (2001) [Pubmed]
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