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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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HNF1alpha controls renal glucose reabsorption in mouse and man.

Recently it has been shown that dominant mutations in the human hepatocyte nuclear factor 1alpha (HNF1alpha) gene, encoding for a homeoprotein that is expressed in liver, kidney, pancreas and intestine, result in maturity onset diabetes of the young type 3 (MODY3). HNF1alpha-null mice are diabetic, but at the same time suffer from a renal Fanconi syndrome characterized by urinary glucose loss. Here we show that MODY3 patients are also characterized by a reduced tubular reabsorption of glucose. The renal murine defect is due to reduced expression of the low affinity/high capacity glucose cotransporter ( SGLT2). Our results show that HNF1alpha directly controls SGLT2 gene expression. Together these data indicate that HNF1alpha plays a key role in glucose homeostasis in mammals.[1]

References

  1. HNF1alpha controls renal glucose reabsorption in mouse and man. Pontoglio, M., Prié, D., Cheret, C., Doyen, A., Leroy, C., Froguel, P., Velho, G., Yaniv, M., Friedlander, G. EMBO Rep. (2000) [Pubmed]
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