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Zawalich, W.S. et al.

Zawalich, Zawalich, Tesz, Sterpka, Philbrick,

Insulin secretion and IP levels in two distant lineages of the genus Mus: comparisons with rat islets.

Islet responses of two different Mus geni, the laboratory mouse (Mus musculus) and a phylogenetically more ancient species (Mus caroli), were measured and compared with the responses of islets from rats (Rattus norvegicus). A minimal and flat second-phase response to 20 mM glucose was evoked from M. musculus islets, whereas a large rising second-phase response characterized rat islets. M. caroli responses were intermediate between these two extremes; a modest rising second-phase response to 20 mM glucose was observed. Prior, brief stimulation of rat islets with 20 mM glucose results in an amplified insulin secretory response to a subsequent 20 mM glucose challenge. No such potentiation or priming was observed from M. musculus islets. In contrast, M. caroli islets displayed a modest twofold potentiated first-phase response upon subsequent restimulation with 20 mM glucose. Inositol phosphate (IP) accumulation in response to 20 mM glucose stimulation in [(3)H]inositol-prelabeled rat or mouse islets paralleled the insulin secretory responses. The divergence in 20 mM glucose-induced insulin release between these species may be attributable to differences in phospholipase C-mediated IP accumulation in islets.[1]

References

Insulin secretion and IP levels in two distant lineages of the genus Mus: comparisons with rat islets. Zawalich, W.S., Zawalich, K.C., Tesz, G.J., Sterpka, J.A., Philbrick, W.M. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]

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