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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates.

The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.[1]

References

  1. In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates. Basco, L.K., Dechy-Cabaret, O., Ndounga, M., Meche, F.S., Robert, A., Meunier, B. Antimicrob. Agents Chemother. (2001) [Pubmed]
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