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Chemical Compound Review

Quinolinamine     quinolin-2-amine

Synonyms: Aminoquinoline, Fragment 19, PubChem5818, CHEMBL61236, SureCN38775, ...
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Disease relevance of Quinolinamine


High impact information on Quinolinamine


Biological context of Quinolinamine

  • [structure: see text] We have previously described a system of 2-aminoquinoline- and 2-aminoquinazoline-based C-deoxynucleosides (TRIPsides) that are designed to be incorporated into oligomers that can specifically bind in the major groove via Hoogsteen base pairing to any sequence of native DNA [7].
  • We synthesized a series of AQs to define the structure-activity relationships responsible for AQ action against chloroquine-susceptible and -resistant P. falciparum [8].
  • In this paper, we report the synthesis of a series of N-benzylated-2-aminoquinolines by reductive amination of aryl aldehydes with 2-aminoquinoline [9].
  • Three copper(II) complexes of aminoquinoline derivatives, l-glycine-N'-8-quinolylamide (L1), l-alanine-N'-8-quinolylamide (L2), and N-(8-quinolyl) pyridine-2-carboxamide (L3) have been shown to cleave plasmid DNA pBR322 and pUC18 with or without the presence of H(2)O(2)/ascorbate [10].

Associations of Quinolinamine with other chemical compounds


  1. Quinoline resistance mechanisms in Plasmodium falciparum: the debate goes on. Ward, S.A., Bray, P.G., Hawley, S.R. Parasitology (1997) [Pubmed]
  2. Antimalarial lichenoid tissue reactions in patients with pre-existing lupus erythematosus. Geraminejad, P., Stone, M.S., Sontheimer, R.D. Lupus (2004) [Pubmed]
  3. Simple synthesis of aminoquinoline/ethylaniline copolymer semiconducting nanoparticles. Li, X.G., Hua, Y.M., Huang, M.R. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  4. Identification and specificity studies of small-molecule ligands for SH3 protein domains. Inglis, S.R., Stojkoski, C., Branson, K.M., Cawthray, J.F., Fritz, D., Wiadrowski, E., Pyke, S.M., Booker, G.W. J. Med. Chem. (2004) [Pubmed]
  5. Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. Apelt, J., Ligneau, X., Pertz, H.H., Arrang, J.M., Ganellin, C.R., Schwartz, J.C., Schunack, W., Stark, H. J. Med. Chem. (2002) [Pubmed]
  6. In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates. Basco, L.K., Dechy-Cabaret, O., Ndounga, M., Meche, F.S., Robert, A., Meunier, B. Antimicrob. Agents Chemother. (2001) [Pubmed]
  7. Synthesis of C-nucleosides designed to participate in triplex formation with native DNA: specific recognition of an A:T base pair in DNA. Li, J.S., Gold, B. J. Org. Chem. (2005) [Pubmed]
  8. Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro. De, D., Krogstad, F.M., Cogswell, F.B., Krogstad, D.J. Am. J. Trop. Med. Hyg. (1996) [Pubmed]
  9. Synthesis of N-benzylated-2-aminoquinolines as ligands for the Tec SH3 domain. Inglis, S.R., Jones, R.K., Booker, G.W., Pyke, S.M. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  10. Steric effect on the nuclease activity of Cu(II) complexes with aminoquinoline derivatives. Shao, Y., Zhang, J., Tu, C., Dai, C., Xu, Q., Guo, Z. J. Inorg. Biochem. (2005) [Pubmed]
  11. Enzyme-triggered formation of electrochemiluminescent ruthenium complexes. Dong, L., Martin, M.T. Anal. Biochem. (1996) [Pubmed]
  12. Effects of antimalarial drugs on interleukin 1-induced cartilage proteoglycan degradation in-vitro. Rainsford, K.D. J. Pharm. Pharmacol. (1986) [Pubmed]
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