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Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene.

Scalarane-type sesterterpenes, PHC-1-PHC-7, which have been isolated from a marine sponge, increased hemoglobin production in human chronic myelogenous leukemia cell line K562 at the concentration of 0.1-5 microg/ml. PHC-1, the major constituent, induced the expression of glycophorin A and the enucleation for K562 cells. These sesterterpenes were found to induce erythroid differentiation in K562 cells. In addition, PHC-1 induced G1 arrest of the cell cycle of K562 cells.[1]


  1. Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene. Aoki, S., Higuchi, K., Isozumi, N., Matsui, K., Miyamoto, Y., Itoh, N., Tanaka, K., Kobayashi, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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