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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Uptake of tritiated D-mannoheptulose by liver, pancreatic exocrine and endocrine cells.

Tritiated D-mannoheptulose, a ketoheptose known to inhibit D-glucose metabolism in hepatocytes and pancreatic islets, but not so in pancreatic acinar cells, was injected intravenously in streptozotocin-induced diabetic mice transplanted under the kidney capsule with islets from control mice of the same strain. One hour after the injection of the tritiated heptose, the radioactive content was 5-8 times higher in the liver and transplanted islets than in the pancreatic gland. It is proposed that suitably radiolabelled D-mannoheptulose could be used to label preferentially the endocrine moiety of the pancreatic gland, e.g., in the perspective of its non-invasive imaging.[1]

References

  1. Uptake of tritiated D-mannoheptulose by liver, pancreatic exocrine and endocrine cells. Crenier, L., Courtois, P., Malaisse, W.J. Int. J. Mol. Med. (2001) [Pubmed]
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