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Chemical Compound Review

STREPTOZOTOCIN     1-methyl-1-nitroso-3- [(3S,4S,5S)-2,4,5...

Synonyms: Prestwick_1047, AC1O4WIW
 
 
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Disease relevance of STREPTOZOTOCIN

 

Psychiatry related information on STREPTOZOTOCIN

 

High impact information on STREPTOZOTOCIN

 

Chemical compound and disease context of STREPTOZOTOCIN

 

Biological context of STREPTOZOTOCIN

 

Anatomical context of STREPTOZOTOCIN

  • We show here that fat cells isolated from streptozotocin diabetic rats and from fasted rats show a significant (60-80%) decrease in the amount of immunologically detectable insulin-sensitive glucose transporter and no change in the level of the Hep G2/rat brain transporter [22].
  • We have observed a dramatic decrease (tenfold) in the steady-state levels of GLUT-4 messenger RNA in adipose tissue from fasted rats or rats made insulin deficient with streptozotocin [23].
  • Complete reversal of streptozotocin-induced diabetes mellitus in adult rats will follow transplantation of a single fetal pancreas if the organ is first grown in a normal syngeneic carrier before transfer to the diabetic recipient [24].
  • Composite grafting of allogeneic islets with syngeneic myoblasts expressing FasL protected the islet graft from immune rejection and maintained normoglycemia for more than 80 days in mice with streptozotocin-induced diabetes [25].
  • Accordingly, young nonobese diabetic (NOD) mice injected with a single low dose of streptozotocin (SZ), a drug cytotoxic for beta cells, exhibited impaired T cell responses to islet antigens and were protected from spontaneous diabetes [19].
 

Associations of STREPTOZOTOCIN with other chemical compounds

 

Gene context of STREPTOZOTOCIN

 

Analytical, diagnostic and therapeutic context of STREPTOZOTOCIN

References

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  18. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Ferber, S., Halkin, A., Cohen, H., Ber, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N., Karasik, A. Nat. Med. (2000) [Pubmed]
  19. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Hugues, S., Mougneau, E., Ferlin, W., Jeske, D., Hofman, P., Homann, D., Beaudoin, L., Schrike, C., Von Herrath, M., Lehuen, A., Glaichenhaus, N. Immunity (2002) [Pubmed]
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  21. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Lamhamedi-Cherradi, S.E., Zheng, S.J., Maguschak, K.A., Peschon, J., Chen, Y.H. Nat. Immunol. (2003) [Pubmed]
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  23. Regulation of glucose transporter messenger RNA in insulin-deficient states. Sivitz, W.I., DeSautel, S.L., Kayano, T., Bell, G.I., Pessin, J.E. Nature (1989) [Pubmed]
  24. Complete reversal of experimental diabetes mellitus in rats by a single fetal pancreas. Mullen, Y.S., Clark, W.R., Molnar, I.G., Brown, J. Science (1977) [Pubmed]
  25. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Lau, H.T., Yu, M., Fontana, A., Stoeckert, C.J. Science (1996) [Pubmed]
  26. Severely impaired adipsin expression in genetic and acquired obesity. Flier, J.S., Cook, K.S., Usher, P., Spiegelman, B.M. Science (1987) [Pubmed]
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  28. Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes. Greene, D.A., De Jesus, P.V., Winegrad, A.I. J. Clin. Invest. (1975) [Pubmed]
  29. Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides. Lynch, C.J., Blackmore, P.F., Johnson, E.H., Wange, R.L., Krone, P.K., Exton, J.H. J. Clin. Invest. (1989) [Pubmed]
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