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Chemical Compound Review

STREPTOZOTOCIN     1-methyl-1-nitroso-3- [(3S,4S,5S)-2,4,5...

Synonyms: Prestwick_1047, AC1O4WIW
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Disease relevance of STREPTOZOTOCIN


Psychiatry related information on STREPTOZOTOCIN


High impact information on STREPTOZOTOCIN


Chemical compound and disease context of STREPTOZOTOCIN


Biological context of STREPTOZOTOCIN


Anatomical context of STREPTOZOTOCIN

  • We show here that fat cells isolated from streptozotocin diabetic rats and from fasted rats show a significant (60-80%) decrease in the amount of immunologically detectable insulin-sensitive glucose transporter and no change in the level of the Hep G2/rat brain transporter [22].
  • We have observed a dramatic decrease (tenfold) in the steady-state levels of GLUT-4 messenger RNA in adipose tissue from fasted rats or rats made insulin deficient with streptozotocin [23].
  • Complete reversal of streptozotocin-induced diabetes mellitus in adult rats will follow transplantation of a single fetal pancreas if the organ is first grown in a normal syngeneic carrier before transfer to the diabetic recipient [24].
  • Composite grafting of allogeneic islets with syngeneic myoblasts expressing FasL protected the islet graft from immune rejection and maintained normoglycemia for more than 80 days in mice with streptozotocin-induced diabetes [25].
  • Accordingly, young nonobese diabetic (NOD) mice injected with a single low dose of streptozotocin (SZ), a drug cytotoxic for beta cells, exhibited impaired T cell responses to islet antigens and were protected from spontaneous diabetes [19].

Associations of STREPTOZOTOCIN with other chemical compounds


Gene context of STREPTOZOTOCIN


Analytical, diagnostic and therapeutic context of STREPTOZOTOCIN


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  2. Treatment of Zollinger-Ellison syndrome with streptozotocin. Stadil, F., Stage, G., Rehfeld, J.F., Efsen, F., Fischerman, K. N. Engl. J. Med. (1976) [Pubmed]
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  4. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Kojima, H., Fujimiya, M., Matsumura, K., Younan, P., Imaeda, H., Maeda, M., Chan, L. Nat. Med. (2003) [Pubmed]
  5. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Bivalacqua, T.J., Champion, H.C., Usta, M.F., Cellek, S., Chitaley, K., Webb, R.C., Lewis, R.L., Mills, T.M., Hellstrom, W.J., Kadowitz, P.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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  7. Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine. Owens, W.A., Sevak, R.J., Galici, R., Chang, X., Javors, M.A., Galli, A., France, C.P., Daws, L.C. J. Neurochem. (2005) [Pubmed]
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  9. Streptozotocin-induced liver tumors in the Syrian hamster. Bell, R.H., Hye, R.J., Miyai, K. Carcinogenesis (1984) [Pubmed]
  10. Elevated plasma proglucagon-like component with a glucagon-secreting tumor. Effect of streptozotocin. Danforth, D.N., Triche, T., Doppman, J.L., Beazley, R.M., Perrino, P.V., Recant, L. N. Engl. J. Med. (1976) [Pubmed]
  11. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nakagawa, Y., Shimano, H., Yoshikawa, T., Ide, T., Tamura, M., Furusawa, M., Yamamoto, T., Inoue, N., Matsuzaka, T., Takahashi, A., Hasty, A.H., Suzuki, H., Sone, H., Toyoshima, H., Yahagi, N., Yamada, N. Nat. Med. (2006) [Pubmed]
  12. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Yoon, J.C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C.R., Granner, D.K., Newgard, C.B., Spiegelman, B.M. Nature (2001) [Pubmed]
  13. A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems. Karnieli, E., Hissin, P.J., Simpson, I.A., Salans, L.B., Cushman, S.W. J. Clin. Invest. (1981) [Pubmed]
  14. Induced and spontaneous diabetes mellitus and suppression of cell-mediated immunologic responses. Granuloma formation, delayed dermal reactivity and allograft rejection. Mahmoud, A.A., Rodman, H.M., Mandel, M.A., Warren, K.S. J. Clin. Invest. (1976) [Pubmed]
  15. Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus. Schambelan, M., Blake, S., Sraer, J., Bens, M., Nivez, M.P., Wahbe, F. J. Clin. Invest. (1985) [Pubmed]
  16. Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo. Giorgino, F., Almahfouz, A., Goodyear, L.J., Smith, R.J. J. Clin. Invest. (1993) [Pubmed]
  17. Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Garcia Soriano F, n.u.l.l., Virág, L., Jagtap, P., Szabó, E., Mabley, J.G., Liaudet, L., Marton, A., Hoyt, D.G., Murthy, K.G., Salzman, A.L., Southan, G.J., Szabó, C. Nat. Med. (2001) [Pubmed]
  18. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Ferber, S., Halkin, A., Cohen, H., Ber, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N., Karasik, A. Nat. Med. (2000) [Pubmed]
  19. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Hugues, S., Mougneau, E., Ferlin, W., Jeske, D., Hofman, P., Homann, D., Beaudoin, L., Schrike, C., Von Herrath, M., Lehuen, A., Glaichenhaus, N. Immunity (2002) [Pubmed]
  20. Islet expression of interferon-alpha precedes diabetes in both the BB rat and streptozotocin-treated mice. Huang, X., Hultgren, B., Dybdal, N., Stewart, T.A. Immunity (1994) [Pubmed]
  21. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Lamhamedi-Cherradi, S.E., Zheng, S.J., Maguschak, K.A., Peschon, J., Chen, Y.H. Nat. Immunol. (2003) [Pubmed]
  22. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Berger, J., Biswas, C., Vicario, P.P., Strout, H.V., Saperstein, R., Pilch, P.F. Nature (1989) [Pubmed]
  23. Regulation of glucose transporter messenger RNA in insulin-deficient states. Sivitz, W.I., DeSautel, S.L., Kayano, T., Bell, G.I., Pessin, J.E. Nature (1989) [Pubmed]
  24. Complete reversal of experimental diabetes mellitus in rats by a single fetal pancreas. Mullen, Y.S., Clark, W.R., Molnar, I.G., Brown, J. Science (1977) [Pubmed]
  25. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Lau, H.T., Yu, M., Fontana, A., Stoeckert, C.J. Science (1996) [Pubmed]
  26. Severely impaired adipsin expression in genetic and acquired obesity. Flier, J.S., Cook, K.S., Usher, P., Spiegelman, B.M. Science (1987) [Pubmed]
  27. Metabolism of peripheral nerve myelin in experimental diabetes. Spritz, N., Singh, H., Marinan, B. J. Clin. Invest. (1975) [Pubmed]
  28. Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes. Greene, D.A., De Jesus, P.V., Winegrad, A.I. J. Clin. Invest. (1975) [Pubmed]
  29. Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides. Lynch, C.J., Blackmore, P.F., Johnson, E.H., Wange, R.L., Krone, P.K., Exton, J.H. J. Clin. Invest. (1989) [Pubmed]
  30. Glomerular basement membrane: biosynthesis and chemical composition in the streptozotocin diabetic rat. Beisswenger, P.J. J. Clin. Invest. (1976) [Pubmed]
  31. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. Anitha, M., Gondha, C., Sutliff, R., Parsadanian, A., Mwangi, S., Sitaraman, S.V., Srinivasan, S. J. Clin. Invest. (2006) [Pubmed]
  32. Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Liadis, N., Murakami, K., Eweida, M., Elford, A.R., Sheu, L., Gaisano, H.Y., Hakem, R., Ohashi, P.S., Woo, M. Mol. Cell. Biol. (2005) [Pubmed]
  33. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Kurlawalla-Martinez, C., Stiles, B., Wang, Y., Devaskar, S.U., Kahn, B.B., Wu, H. Mol. Cell. Biol. (2005) [Pubmed]
  34. Octreotide prevents the early increase in renal insulin-like growth factor binding protein 1 in streptozotocin diabetic rats. Raz, I., Rubinger, D., Popovtzer, M., Grønbaek, H., Weiss, O., Flyvbjerg, A. Diabetes (1998) [Pubmed]
  35. Glomerulopathy in rats with streptozotocin diabetes. Accumulation of glomerular basement membrane analogous to human diabetic nephropathy. Cohen, M.P., Klein, C.V. J. Exp. Med. (1979) [Pubmed]
  36. Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. Nie, Y., Nakashima, M., Brubaker, P.L., Li, Q.L., Perfetti, R., Jansen, E., Zambre, Y., Pipeleers, D., Friedman, T.C. J. Clin. Invest. (2000) [Pubmed]
  37. Beta cell expression of IGF-I leads to recovery from type 1 diabetes. George, M., Ayuso, E., Casellas, A., Costa, C., Devedjian, J.C., Bosch, F. J. Clin. Invest. (2002) [Pubmed]
  38. An anomaly of insulin removal in perfused livers of obese-hyperglycemic (ob/ob) mice. Karakash, C., Assimacopoulos-Jeannet, F., Jeanrenaud, B. J. Clin. Invest. (1976) [Pubmed]
  39. Parvalbumin is reduced in the peripheral nerves of diabetic rats. Endo, T., Onaya, T. J. Clin. Invest. (1986) [Pubmed]
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