The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound

Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

[search][options]

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Tanaka, Y. et al.

Tanaka, Shigenobu, Nakayama,

Effects of endothelin-1 on the myogenic contraction of canine cerebral artery in response to quick stretch.

The present study was performed to investigate the effects of endothelin-1 (ET-1) on the myogenic contraction in response to mechanical stimulation in cerebral artery. Quick stretch at a rate of 10 cm/sec with the amount of 10 - 40% of the initial muscle length (=100%) produced a myogenic contraction in canine cerebral artery. ET-1 at 30 pM, which itself produces a small contraction corresponding to about 15% of the maximal response, potentiated stretch-induced contraction. By contrast, ET-1 at concentrations over 100 pM suppressed the stretch-induced tone. The potentiated component of stretch-induced tone in the presence of 30 pM ET-1 was largely attenuated by Ca2+ channel blockers, nimodipine (1 microM) or diltiazem (1 microM). These findings suggest that lower concentrations (pM range) of ET- 1 potentiates myogenic tension development of cerebral artery in response to mechanical stretch possibly via an increased Ca2+ influx through voltage-gated Ca2+ channel.[1]

References

Effects of endothelin-1 on the myogenic contraction of canine cerebral artery in response to quick stretch. Tanaka, Y., Shigenobu, K., Nakayama, K. Res. Commun. Mol. Pathol. Pharmacol. (2001) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg