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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes.

At concentrations of 2mM and above hydroxypyruvate produced no glucose with isolated rat liver cells, although it was rapidly utilized. At a lower concentration of hydroxypyruvate or in the presence of substrates which generate reducing equivalents (ethanol or butyrate), appreciable amounts of glucose were formed from hydroxypyruvate. A possible explanation for this phenomenon is discussed.[1]


  1. Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes. Williamson, D.H., Ellington, E.V. Biochem. J. (1975) [Pubmed]
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