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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Anticonvulsant and sedative effects of some 5-substituted bromopyrazolinic spirobarbiturates.

We studied in mice the neuropharmacological effect of some 5-substituted bromopyrazolinic spirobarbiturates. LD50 and CL50 values were estimated for all the investigated compounds. The effect on potentiation of sodium pentobarbital activity and on generalised tonic-clonic seizures produced by PTZ on mice was studied. All the compounds had the same pharmacological profile, they extended sleeping-time induced by sodium pentobarbital and showed protection against PTZ-induced convulsions, decreasing the death rate.[1]

References

  1. Anticonvulsant and sedative effects of some 5-substituted bromopyrazolinic spirobarbiturates. Galati, E.M., Monforte, M.T., Miceli, N., Raneri, E. Farmaco (2001) [Pubmed]
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