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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Seizures


Psychiatry related information on Seizures


High impact information on Seizures


Chemical compound and disease context of Seizures


Biological context of Seizures


Anatomical context of Seizures


Gene context of Seizures

  • Kir6.2-containing KATP channels in brain also are involved in protection from hypoxia-induced generalized seizure [29].
  • Mice lacking this enzyme (Pcmt1-/- mice) have elevated levels of damaged residues and die at a mean age of 42 days from massive tonic-clonic seizures [30].
  • This study confirms a causative role of EJM1 in the pathogenesis of idiopathic generalized seizures in the majority of German families of JME patients and refines a candidate region of 10.1 cM in the chromosomal region 6p21 between the flanking loci HLA-DQ and D6S1019 [31].
  • Selective coexpression of NR2A/B and NR1 in dysplastic neurons suggests that NR2A/B may form heteromeric NR1-NR2 coassemblies and hyperexcitability in dysplastic neurons that could contribute to focal seizure onset [32].
  • The deficit in the NT-3+/- mice reflected dampening of the progression from focal to generalized seizures [33].

Analytical, diagnostic and therapeutic context of Seizures


  1. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Woldbye, D.P., Larsen, P.J., Mikkelsen, J.D., Klemp, K., Madsen, T.M., Bolwig, T.G. Nat. Med. (1997) [Pubmed]
  2. Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Yamada, K., Ji, J.J., Yuan, H., Miki, T., Sato, S., Horimoto, N., Shimizu, T., Seino, S., Inagaki, N. Science (2001) [Pubmed]
  3. Valproic acid (Depakene). A new anticonvulsant agent. Lewis, J.R. JAMA (1978) [Pubmed]
  4. A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31. Cormier-Daire, V., Dagoneau, N., Nabbout, R., Burglen, L., Penet, C., Soufflet, C., Desguerre, I., Munnich, A., Dulac, O. Am. J. Hum. Genet. (2000) [Pubmed]
  5. Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1). Lalioti, M.D., Mirotsou, M., Buresi, C., Peitsch, M.C., Rossier, C., Ouazzani, R., Baldy-Moulinier, M., Bottani, A., Malafosse, A., Antonarakis, S.E. Am. J. Hum. Genet. (1997) [Pubmed]
  6. Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid. Iadarola, M.J., Gale, K. Science (1982) [Pubmed]
  7. Successful use of alternate waste nitrogen agents and hemodialysis in a patient with hyperammonemic coma after heart-lung transplantation. Berry, G.T., Bridges, N.D., Nathanson, K.L., Kaplan, P., Clancy, R.R., Lichtenstein, G.R., Spray, T.L. Arch. Neurol. (1999) [Pubmed]
  8. Prediction of outcome based on clinical seizure type in newborn infants. Brunquell, P.J., Glennon, C.M., DiMario, F.J., Lerer, T., Eisenfeld, L. J. Pediatr. (2002) [Pubmed]
  9. The macrostructure and microstructure of sleep in patients with autosomal dominant nocturnal frontal lobe epilepsy. Zucconi, M., Oldani, A., Smirne, S., Ferini-Strambi, L. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (2000) [Pubmed]
  10. Hallucinations on withdrawal of isoflurane used as sedation. Hughes, J., Leach, H.J., Choonara, I. Acta Paediatr. (1993) [Pubmed]
  11. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. Alldredge, B.K., Gelb, A.M., Isaacs, S.M., Corry, M.D., Allen, F., Ulrich, S., Gottwald, M.D., O'Neil, N., Neuhaus, J.M., Segal, M.R., Lowenstein, D.H. N. Engl. J. Med. (2001) [Pubmed]
  12. Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Hogema, B.M., Gupta, M., Senephansiri, H., Burlingame, T.G., Taylor, M., Jakobs, C., Schutgens, R.B., Froestl, W., Snead, O.C., Diaz-Arrastia, R., Bottiglieri, T., Grompe, M., Gibson, K.M. Nat. Genet. (2001) [Pubmed]
  13. Risk of recurrent seizures after two unprovoked seizures. Hauser, W.A., Rich, S.S., Lee, J.R., Annegers, J.F., Anderson, V.E. N. Engl. J. Med. (1998) [Pubmed]
  14. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. Trevathan, E., Mullens, E.L., Manasco, P. N. Engl. J. Med. (1998) [Pubmed]
  15. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. Mattson, R.H., Cramer, J.A., Collins, J.F. N. Engl. J. Med. (1992) [Pubmed]
  16. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. Mattson, R.H., Cramer, J.A., Collins, J.F., Smith, D.B., Delgado-Escueta, A.V., Browne, T.R., Williamson, P.D., Treiman, D.M., McNamara, J.O., McCutchen, C.B. N. Engl. J. Med. (1985) [Pubmed]
  17. Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion. Haberman, R.P., Samulski, R.J., McCown, T.J. Nat. Med. (2003) [Pubmed]
  18. A crucial epileptogenic site in the deep prepiriform cortex. Piredda, S., Gale, K. Nature (1985) [Pubmed]
  19. Changes of hippocampal Met-enkephalin content after recurrent motor seizures. Hong, J.S., Wood, P.L., Gillin, J.C., Yang, H.Y., Costa, E. Nature (1980) [Pubmed]
  20. Childhood absence epilepsy with tonic-clonic seizures and electroencephalogram 3-4-Hz spike and multispike-slow wave complexes: linkage to chromosome 8q24. Fong, G.C., Shah, P.U., Gee, M.N., Serratosa, J.M., Castroviejo, I.P., Khan, S., Ravat, S.H., Mani, J., Huang, Y., Zhao, H.Z., Medina, M.T., Treiman, L.J., Pineda, G., Delgado-Escueta, A.V. Am. J. Hum. Genet. (1998) [Pubmed]
  21. Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2. Kearney, J.A., Yang, Y., Beyer, B., Bergren, S.K., Claes, L., Dejonghe, P., Frankel, W.N. Hum. Mol. Genet. (2006) [Pubmed]
  22. Childhood generalized and mesial temporal epilepsies demonstrate different amounts and patterns of hippocampal neuron loss and mossy fibre synaptic reorganization. Mathern, G.W., Babb, T.L., Mischel, P.S., Vinters, H.V., Pretorius, J.K., Leite, J.P., Peacock, W.J. Brain (1996) [Pubmed]
  23. Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity. Haberman, R., Criswell, H., Snowdy, S., Ming, Z., Breese, G., Samulski, R., McCown, T. Mol. Ther. (2002) [Pubmed]
  24. CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy. Phillips, H.A., Favre, I., Kirkpatrick, M., Zuberi, S.M., Goudie, D., Heron, S.E., Scheffer, I.E., Sutherland, G.R., Berkovic, S.F., Bertrand, D., Mulley, J.C. Am. J. Hum. Genet. (2001) [Pubmed]
  25. The role of the piriform cortex in kindling. Löscher, W., Ebert, U. Prog. Neurobiol. (1996) [Pubmed]
  26. Endogenous neurotrophin-3 regulates short-term plasticity at lateral perforant path-granule cell synapses. Kokaia, M., Asztely, F., Olofsdotter, K., Sindreu, C.B., Kullmann, D.M., Lindvall, O. J. Neurosci. (1998) [Pubmed]
  27. Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy. Jokeit, H., Seitz, R.J., Markowitsch, H.J., Neumann, N., Witte, O.W., Ebner, A. Brain (1997) [Pubmed]
  28. Sleep and temporal lobe epilepsy: a case study with depth electrodes. Montplaisir, J., Laverdière, M., Saint-Hilaire, J.M., Walsh, J., Bouvier, G. Neurology (1981) [Pubmed]
  29. Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice. Minami, K., Miki, T., Kadowaki, T., Seino, S. Diabetes (2004) [Pubmed]
  30. Limited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice. Lowenson, J.D., Kim, E., Young, S.G., Clarke, S. J. Biol. Chem. (2001) [Pubmed]
  31. Refined mapping of the epilepsy susceptibility locus EJM1 on chromosome 6. Sander, T., Bockenkamp, B., Hildmann, T., Blasczyk, R., Kretz, R., Wienker, T.F., Volz, A., Schmitz, B., Beck-Mannagetta, G., Riess, O., Epplen, J.T., Janz, D., Ziegler, A. Neurology (1997) [Pubmed]
  32. Selective coexpression of NMDAR2A/B and NMDAR1 subunit proteins in dysplastic neurons of human epileptic cortex. Ying, Z., Babb, T.L., Mikuni, N., Najm, I., Drazba, J., Bingaman, W. Exp. Neurol. (1999) [Pubmed]
  33. Suppressed kindling epileptogenesis and perturbed BDNF and TrkB gene regulation in NT-3 mutant mice. Elmér, E., Kokaia, M., Ernfors, P., Ferencz, I., Kokaia, Z., Lindvall, O. Exp. Neurol. (1997) [Pubmed]
  34. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Minowa, O., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., Miyawaki, A., Fukuuchi, Y., Furuichi, T., Okano, H., Mikoshiba, K., Noda, T. Nature (1996) [Pubmed]
  35. Brain chimeras in birds: application to the study of a genetic form of reflex epilepsy. Batini, C., Teillet, M.A., Naquet, R., Le Douarin, N.M. Trends Neurosci. (1996) [Pubmed]
  36. The role of positron emission tomography in the evaluation of seizure disorders. Theodore, W.H., Brooks, R., Sato, S., Patronas, N., Margolin, R., Di Chiro, G., Porter, R.J. Ann. Neurol. (1984) [Pubmed]
  37. Quantitative MRI in patients with idiopathic generalized epilepsy. Evidence of widespread cerebral structural changes. Woermann, F.G., Sisodiya, S.M., Free, S.L., Duncan, J.S. Brain (1998) [Pubmed]
  38. Carbamazepine--a double-blind comparison with phenytoin. Troupin, A., Ojemann, L.M., Halpern, L., Dodrill, C., Wilkus, R., Friel, P., Feigl, P. Neurology (1977) [Pubmed]
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