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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation.

Many hematopoietic cells undergo apoptosis when deprived of specific cytokines, and this process requires de novo RNA/protein synthesis. Using DNA microarrays to analyze interleukin-3 (IL-3)-dependent murine FL5.12 pro-B cells, we found that the gene undergoing maximal transcriptional induction after cytokine withdrawal is 24p3, which encodes a secreted lipocalin. Conditioned medium from IL-3-deprived FL5.12 cells contained 24p3 and induced apoptosis in naive FL5.12 cells even when IL-3 was present. 24p3 also induced apoptosis in a wide variety of leukocytes but not other cell types. Apoptotic sensitivity correlated with the presence of a putative 24p3 cell surface receptor. We conclude that IL-3 deprivation activates 24p3 transcription, leading to synthesis and secretion of 24p3, which induces apoptosis through an autocrine pathway.[1]

References

  1. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Devireddy, L.R., Teodoro, J.G., Richard, F.A., Green, M.R. Science (2001) [Pubmed]
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