Gene Review:
Il3 - interleukin 3
Mus musculus
Synonyms:
BPA, Csfmu, HCGF, Hematopoietic growth factor, IL-3, ...
- Differentiation state and responses to hematopoietic growth factors of murine myeloid cells transformed by myb. Gonda, T.J., Macmillan, E.M., Townsend, P.V., Hapel, A.J. Blood (1993)
- Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells. Lotem, J., Sachs, L. Blood (1992)
- Expression of the interleukin-3 and granulocyte-macrophage colony-stimulating factor genes in Friend spleen focus-forming virus-induced erythroleukemia. Shimada, Y., Migliaccio, G., Ruscetti, S., Adamson, J.W., Migliaccio, A.R. Blood (1992)
- Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo. Jiang, X., Ng, E., Yip, C., Eisterer, W., Chalandon, Y., Stuible, M., Eaves, A., Eaves, C.J. Blood (2002)
- Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions. Nishinakamura, R., Miyajima, A., Mee, P.J., Tybulewicz, V.L., Murray, R. Blood (1996)
- Keratinocyte-derived interleukin 3. Luger, T.A., Kock, A., Kirnbauer, R., Schwarz, T., Ansel, J.C. Ann. N. Y. Acad. Sci. (1988)
- A v-H-ras-dependent hemopoietic tumor model involving progression from a clonal stage of transformation competence to autocrine interleukin 3 production. Nair, A.P., Diamantis, I.D., Conscience, J.F., Kindler, V., Hofer, P., Moroni, C. Mol. Cell. Biol. (1989)
- The panspecific hemopoietin of activated T lymphocytes (interleukin-3). Schrader, J.W. Annu. Rev. Immunol. (1986)
- A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Devireddy, L.R., Gazin, C., Zhu, X., Green, M.R. Cell (2005)
- Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Fairbairn, L.J., Cowling, G.J., Reipert, B.M., Dexter, T.M. Cell (1993)
- IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Shibuya, H., Yoneyama, M., Ninomiya-Tsuji, J., Matsumoto, K., Taniguchi, T. Cell (1992)
- Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation. Just, U., Stocking, C., Spooncer, E., Dexter, T.M., Ostertag, W. Cell (1991)
- Interleukin-3 enhances cytokine production by LPS-stimulated macrophages. Cohen, L., David, B., Cavaillon, J.M. Immunol. Lett. (1991)
- In-vivo effect of interleukin 3 and erythropoietin, either alone or in combination, on the hematopoietic toxicity associated with zidovudine. Gallicchio, V.S., Hughes, N.K., Tse, K.F. Cytokine (1993)
- Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis. Nieborowska-Skorska, M., Wasik, M.A., Slupianek, A., Salomoni, P., Kitamura, T., Calabretta, B., Skorski, T. J. Exp. Med. (1999)
- The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1. Wheeler, E.F., Askew, D., May, S., Ihle, J.N., Sherr, C.J. Mol. Cell. Biol. (1987)
- Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation. Derigs, H.G., Klingberg, D., Tricot, G.J., Boswell, H.S. Blood (1989)
- Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Itoh, N., Yonehara, S., Schreurs, J., Gorman, D.M., Maruyama, K., Ishii, A., Yahara, I., Arai, K., Miyajima, A. Science (1990)
- Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression. Schmitt, R.M., Bruyns, E., Snodgrass, H.R. Genes Dev. (1991)
- Transforming growth factor beta 1 is an inducer of erythroid differentiation. Krystal, G., Lam, V., Dragowska, W., Takahashi, C., Appel, J., Gontier, A., Jenkins, A., Lam, H., Quon, L., Lansdorp, P. J. Exp. Med. (1994)
- Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony-stimulating factor-1, and recombinant murine granulocyte-macrophage colony-stimulating factor on myelopoiesis in mice. Broxmeyer, H.E., Williams, D.E., Cooper, S., Shadduck, R.K., Gillis, S., Waheed, A., Urdal, D.L., Bicknell, D.C. J. Clin. Invest. (1987)
- B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Brown, M.A., Pierce, J.H., Watson, C.J., Falco, J., Ihle, J.N., Paul, W.E. Cell (1987)
- Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32D. Migliaccio, G., Migliaccio, A.R., Kreider, B.L., Rovera, G., Adamson, J.W. J. Cell Biol. (1989)
- Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3). Barlow, D.P., Bućan, M., Lehrach, H., Hogan, B.L., Gough, N.M. EMBO J. (1987)
- Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3). Hara, T., Miyajima, A. EMBO J. (1992)
- Stimulation of multipotential, erythroid and other murine haematopoietic progenitor cells by adherent cell lines in the absence of detectable multi-CSF (IL-3). Li, C.L., Johnson, G.R. Nature (1985)
- Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. Murakami, M., Penrose, J.F., Urade, Y., Austen, K.F., Arm, J.P. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Negative regulation by interleukin-3 (IL-3) of mouse early B-cell progenitors and stem cells in culture: transduction of the negative signals by betac and betaIL-3 proteins of IL-3 receptor and absence of negative regulation by granulocyte-macrophage colony-stimulating factor. Matsunaga, T., Hirayama, F., Yonemura, Y., Murray, R., Ogawa, M. Blood (1998)
- The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in vitro. Namikawa, R., Muench, M.O., de Vries, J.E., Roncarolo, M.G. Blood (1996)
- Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation. Calvo, V., Wood, M., Gjertson, C., Vik, T., Bierer, B.E. Eur. J. Immunol. (1994)
- Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cells. Ryan, J.J., Huang, H., McReynolds, L.J., Shelburne, C., Hu-Li, J., Huff, T.F., Paul, W.E. Exp. Hematol. (1997)
- Expression of IL-3 receptor in testis. Morikawa, Y., Tohya, K., Hara, T., Kitamura, T., Miyajima, A. Biochem. Biophys. Res. Commun. (1996)
- Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. Conrad, D.H., Ben-Sasson, S.Z., Le Gros, G., Finkelman, F.D., Paul, W.E. J. Exp. Med. (1990)
- P210 Bcr-Abl interacts with the interleukin 3 receptor beta(c) subunit and constitutively induces its tyrosine phosphorylation. Wilson-Rawls, J., Xie, S., Liu, J., Laneuville, P., Arlinghaus, R.B. Cancer Res. (1996)
- Signal transduction by a CD16/CD7/Jak2 fusion protein. Sakai, I., Nabell, L., Kraft, A.S. J. Biol. Chem. (1995)
- Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. del Peso, L., González-García, M., Page, C., Herrera, R., Nuñez, G. Science (1997)
- Tec protein-tyrosine kinase directly associates with Lyn protein-tyrosine kinase through its N-terminal unique domain. Mano, H., Sato, K., Yazaki, Y., Hirai, H. Oncogene (1994)
- Interleukin-3 signals through multiple isoforms of Stat5. Azam, M., Erdjument-Bromage, H., Kreider, B.L., Xia, M., Quelle, F., Basu, R., Saris, C., Tempst, P., Ihle, J.N., Schindler, C. EMBO J. (1995)
- Interferon-gamma stimulates the survival and influences the development of bipotential granulocyte-macrophage colony-forming cells. Kan, O., Heyworth, C.M., Dexter, T.M., Maudsley, P.J., Cook, N., Vallance, S.J., Whetton, A.D. Blood (1991)
- Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3. Jegalian, A.G., Acurio, A., Dranoff, G., Wu, H. Blood (2002)
- Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells. Mu, S.X., Xia, M., Elliott, G., Bogenberger, J., Swift, S., Bennett, L., Lappinga, D.L., Hecht, R., Lee, R., Saris, C.J. Blood (1995)
- Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma. Bradley, L.M., Duncan, D.D., Tonkonogy, S., Swain, S.L. J. Exp. Med. (1991)
- Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Ikebuchi, K., Wong, G.G., Clark, S.C., Ihle, J.N., Hirai, Y., Ogawa, M. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7. Orlic, D., Anderson, S., Biesecker, L.G., Sorrentino, B.P., Bodine, D.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Gerondakis, S., Strasser, A., Metcalf, D., Grigoriadis, G., Scheerlinck, J.Y., Grumont, R.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Identification of 24p3 as a direct target of Foxo3a regulated by interleukin-3 through the phosphoinositide 3-kinase/Akt pathway. Park, S., Guo, J., Kim, D., Cheng, J.Q. J. Biol. Chem. (2009)
- Murine pluripotent hematopoietic progenitors constitutively expressing a normal erythropoietin receptor proliferate in response to erythropoietin without preferential erythroid cell differentiation. Dubart, A., Feger, F., Lacout, C., Goncalves, F., Vainchenker, W., Dumenil, D. Mol. Cell. Biol. (1994)
- A soluble activity from adherent marrow cells cooperates with IL 3 in stimulating growth of pluripotential hematopoietic precursors. Iscove, N.N., Fagg, B., Keller, G. Blood (1988)
- Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma. Kittler, E.L., McGrath, H., Temeles, D., Crittenden, R.B., Kister, V.K., Quesenberry, P.J. Blood (1992)
- Apoptosis and hematopoiesis in murine fetal liver. Yu, H., Bauer, B., Lipke, G.K., Phillips, R.L., Van Zant, G. Blood (1993)