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Ghaemi, S.N. et al.

Ghaemi, Lenox, Baldessarini,

Effectiveness and safety of long-term antidepressant treatment in bipolar disorder.

OBJECTIVE: We sought to review research on use of antidepressants for long-term treatment of bipolar depression. METHOD: We conducted a computerized literature search of the MEDLINE, HealthStar, Current Contents, PsychInfo, and National Library of Medicine databases to identify studies involving antidepressant, anticonvulsant, or lithium use in bipolar disorder or manic-depressive illness published from 1966 through 2000. RESULTS: Only 7 blinded, controlled trials of long-term antidepressant treatment in bipolar disorders were found. The available information is not adequate to support the safety or effectiveness of long-term antidepressant treatment for bipolar depression, with or without mood-stabilizing cotherapy. CONCLUSION: Antidepressant treatment of bipolar depression is extraordinarily understudied. Controlled trials comparing specific antidepressants, particularly to compare mood-stabilizing agents given alone and combined with an antidepressant, are needed.[1]

References

Effectiveness and safety of long-term antidepressant treatment in bipolar disorder. Ghaemi, S.N., Lenox, M.S., Baldessarini, R.J. The Journal of clinical psychiatry. (2001) [Pubmed]

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