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Kozawa, O. et al.

Kozawa, Hatakeyama, Yoshida, Kamiya, Kondo, Matsuno, Uematsu,

Activation of p44/ p42 mitogen- activated protein kinase limits triiodothyronine- stimulated alkaline phosphatase activity in osteoblasts.

It has been shown that thyroid hormone stimulates the activity of alkaline phosphatase, a marker of mature osteoblast phenotype, in osteoblasts. In the present study, we investigated whether p44/ p42 mitogen- activated protein (MAP) kinase is involved in the thyroid hormone- stimulated alkaline phosphatase activity in osteoblast-like MC3T3-E1 cells. Triiodothyronine (T(3)) markedly induced the phosphorylation of p44/p42 MAP kinase. PD98059 and U0126, inhibitors of the upstream kinase that activates p44/p42 MAP kinase, significantly enhanced the T(3)-induced alkaline phosphatase activity in a dose-dependent manner. The phosphorylation of p44/p42 MAP kinase induced by T(3) was reduced by U0126. These results strongly suggest that p44/p42 MAP kinase takes part in the thyroid hormone- stimulated alkaline phosphatase activity in osteoblasts and that p44/p42 MAP kinase plays an inhibitory role in the thyroid hormone-effect.[1]

References

Activation of p44/p42 mitogen-activated protein kinase limits triiodothyronine-stimulated alkaline phosphatase activity in osteoblasts. Kozawa, O., Hatakeyama, D., Yoshida, M., Kamiya, Y., Kondo, C., Matsuno, H., Uematsu, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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