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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The bet gene of feline foamy virus is required for virus replication.

Foamy viruses (FV) are complex retroviruses with additional bel genes located between env and the 3' long-terminal repeat. The functions of the bel 2 and bet genes are unknown and both are dispensable for replication of the prototypic human foamy virus in cell cultures. We examined the function(s) of bel 2 and bet of the distantly related feline foamy virus (FFV) in the proviral context. Mutagenesis was used to alter the Bel 2 and Bet or to abrogate their expression. The Bel 2/ Bet mutants showed a 1000-fold reduced viral titer in feline kidney cells; in human 293T cells, viral titer was only about 10-fold reduced compared to wild-type FFV. In both cell types, the Bel 2/ Bet mutations resulted in a reduced release of FFV particles. The results indicate that FFV Bet is required for efficient virus replication. The functions of the Bel 2 and Bet proteins are discussed.[1]


  1. The bet gene of feline foamy virus is required for virus replication. Alke, A., Schwantes, A., Kido, K., Flötenmeyer, M., Flügel, R.M., Löchelt, M. Virology (2001) [Pubmed]
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