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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The acidity of chloro-substituted benzenes: a comparison of gas phase, ab initio, and kinetic data.

The deprotonation energies of benzene, chlorobenzene, all di-, tri-, tetrachlorobenzenes, and pentachlorobenzene have been determined in the gas phase using a Fourier transform ion cyclotron resonance mass spectrometer. The values measured differ only slightly, though significantly, from the corresponding data for oligofluorobenzenes. The heavier halogen acidifies orthopositions slightly less and meta-positions slightly more than fluorine does. Moreover, the contributions of three or more chloro substituents are not perfectly additive. In fact the accumulation attenuates the contributions somewhat. Quantum chemical calculations at the MP2/6-311+G* level reproduce the gas-phase acidities fairly well, but reveal special effects when extended to experimentally not observable benzenides carrying the halogens at anion-remote positions. Competition experiments have been performed to assess the relative reactivity of nine oligochlorobenzenes towards sec-butyllithium in tetrahydrofuran at -100 degrees C. An almost exact linear correlation between logarithmic rates and gas-phase acidities has been found.[1]

References

  1. The acidity of chloro-substituted benzenes: a comparison of gas phase, ab initio, and kinetic data. Schlosser, M., Marzi, E., Cottet, F., Büker, H.H., Nibbering, N.M. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
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