Disease relevance of NSC27003

• The tecB gene, located downstream of tecA and encoding tetrachlorobenzene dioxygenase, in Ralstonia sp. strain PS12 was cloned into Escherichia coli DH5alpha together with the tecA gene [1].
• Escherichia coli cells producing recombinant TecA enzyme dioxygenate and simultaneously eliminate a halogen substituent from 1,2,4,5-tetrachlorobenzene but show no activity toward benzene, whereas those producing TodCBA dioxygenate benzene but not tetrachlorobenzene [2].
• The results demonstrate that Rhodococcus sp. strain MS11 may be well suited for bioremediation of soils and sediments contaminated for a long time with di-, tri- and tetrachlorobenzenes as well as alkanes [3].
• The bacterium, Burkholderia (previously Pseudomonas) sp. strain PS12, reported earlier to degrade 1,2,4-trichlorobenzene is shown here to utilize also 1,2,4,5-tetrachlorobenzene (Cl4-benzene) as a growth substrate [4].
• The presence of suspended or colloidal 1,2,4,5-tetrachlorobenzene was observed in acute toxicity testing and affected toxicity estimates [5].

High impact information on NSC27003

• The average turnover frequency at 120 degrees C in 1,2,4,5-tetrachlorobenzene/toluene is estimated at >6 x 10(6) g of polymethylene (mol boron)(-1) h(-1) [6].
• Of 20 halogenated benzenes tested, only 1,2,4,5-tetrachlorobenzene and hexachlorobenzene promoted the occurrence of DENA-initiated GGT foci [7].
• While TECB, PECB, and HCB all significantly increased foci volume, only HCB increased normal hepatocyte proliferation [8].
• Sorption of phenanthrene to Ag(+)-saturated montmorillonite was much stronger compared with 1,2,4,5-tetrachlorobenzene, a coplanar non-pi donor having slightly higher hydrophobicity [9].
• In this study the elimination kinetics of several chlorinated anilines and a tetrachlorobenzene in guppy, Poecilia reticulata, have been determined [10].

Chemical compound and disease context of NSC27003

• Effect of phenobarbital and polychlorinated biphenyls on the toxicity and disposition of 1,2,4,5-tetrachlorobenzene in the rat [11].

Biological context of NSC27003

• Three tetrachlorobenzene (TCB) congeners (1,2,3,4- 1,2,3,5-, and 1,2,4,5-) were administered daily by gavage to pregnant Sprague-Dawley rats at levels of 50, 100, or 200 mg/kg from day 6 through day 15 of gestation [12].
• The maternal hepatic microsomal enzyme induction observed after TCB administration to pregnant rats suggests the presence both cytochrome P-450 and P-448 inducers in the sample of 1,2,4,5-tetrachlorobenzene used [13].

Anatomical context of NSC27003

• Maternal hepatic effects of 1,2,4,5-tetrachlorobenzene in the rat [13].
• A teratological evaluation and analysis of fetal tissue levels following administration of tetrachlorobenzene isomers to the rat [12].
• There was no evidence for the presence of hexachloro-1,3-butadiene, Mirex, octachlorostyrene, chlorinated naphthalenes or tetrachlorobenzenes in the breast milk [14].
• Adult male rats were given orally single doses of 14C-labeled 1,2,3,4-, 1,2,3,5-, or 1,2,4,5-tetrachlorobenzene (TCB) at 10 mg/kg body weight, and were housed in individual metabolism cages to collect urine and feces for radioassay [15].

Associations of NSC27003 with other chemical compounds

• Residues of PeCB were detected in serum, feces, and adipose and muscle tissues for 120 days post-treatment; TeCB residues were detected in feces and serum at 1 and 8 days post-treatment and in adipose tissue at 30 days post-treatment [16].

Analytical, diagnostic and therapeutic context of NSC27003

• Single-crystal X-ray and neutron powder diffraction investigation of the phase transition in tetrachlorobenzene [17].

References