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Chemical Compound Review

PeCB     1,2,3,4,5-pentachlorobenzene

Synonyms: CHEMBL44628, NSC-1857, CCRIS 5927, AG-G-21453, ACMC-209mn0, ...
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Disease relevance of 608-93-5

  • We reported previously that the F87W/Y96F/V247L mutant of cytochrome P-450cam (CYP101) from Pseudomonas putida catalyzed the rapid oxidation of lightly chlorinated benzenes, but pentachlorobenzene oxidation was slow (Jones, J. P., O'Hare, E. J., and Wong, L. L. (2001) Eur. J. Biochem. 268, 1460-1467) [1].
  • Time-dependent lethal body residues for the toxicity of pentachlorobenzene to Hyalella azteca [2].
  • Thymus and spleen weights relative to body weight were increased after 4 weeks of exposure by inhalation but not after 8 or 12 weeks of exposure. alpha-, beta-, and delta- Benzenehexachlorides , pentachlorobenzene, and hexachlorobenzene were detected in liver tissue from these animals [3].

High impact information on 608-93-5


Chemical compound and disease context of 608-93-5


Biological context of 608-93-5


Anatomical context of 608-93-5


Associations of 608-93-5 with other chemical compounds


Analytical, diagnostic and therapeutic context of 608-93-5

  • When a reference chemical, such as pCBz, is included, the gill perfusion experiments can be highly suitable to determine uptake rate constants of organic chemicals, which can be extrapolated to fish of different sizes [21].


  1. Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene. Chen, X., Christopher, A., Jones, J.P., Bell, S.G., Guo, Q., Xu, F., Rao, Z., Wong, L.L. J. Biol. Chem. (2002) [Pubmed]
  2. Time-dependent lethal body residues for the toxicity of pentachlorobenzene to Hyalella azteca. Landrum, P.F., Steevens, J.A., Gossiaux, D.C., McElroy, M., Robinson, S., Begnoche, L., Chernyak, S., Hickey, J. Environ. Toxicol. Chem. (2004) [Pubmed]
  3. Subchronic exposure of mice to Love Canal soil contaminants. Silkworth, J.B., McMartin, D.N., Rej, R., Narang, R.S., Stein, V.B., Briggs, R.G., Kaminsky, L.S. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1984) [Pubmed]
  4. The acidity of chloro-substituted benzenes: a comparison of gas phase, ab initio, and kinetic data. Schlosser, M., Marzi, E., Cottet, F., Büker, H.H., Nibbering, N.M. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
  5. Viscous indigestible polysaccharides reduce accumulation of pentachlorobenzene in rats. Ikegami, S., Umegaki, K., Kawashima, Y., Ichikawa, T. J. Nutr. (1994) [Pubmed]
  6. Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes. Stewart, F.P., Smith, A.G. Biochem. Pharmacol. (1986) [Pubmed]
  7. Physical-chemical and maternal determinants of the accumulation of organochlorine compounds in four-year-old children. Carrizo, D., Grimalt, J.O., Ribas-Fito, N., Sunyer, J., Torrent, M. Environ. Sci. Technol. (2006) [Pubmed]
  8. Utilization and degradation of lindane by soil microorganisms. Tu, C.M. Arch. Microbiol. (1976) [Pubmed]
  9. Comparative toxicity of fluoranthene and pentachlorobenzene to three freshwater invertebrates. Schuler, L.J., Landrum, P.F., Lydy, M.J. Environ. Toxicol. Chem. (2006) [Pubmed]
  10. Effects of temperature on the toxicity of m-parathion, chlorpyrifos, and pentachlorobenzene to Chironomus tentans. Lydy, M.J., Belden, J.B., Ternes, M.A. Arch. Environ. Contam. Toxicol. (1999) [Pubmed]
  11. Physiological modes of action of toxic chemicals in the nematode Acrobeloides nanus. Alvarez, O.A., Jager, T., Redondo, E.M., Kammenga, J.E. Environ. Toxicol. Chem. (2006) [Pubmed]
  12. Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: a major role for quinone metabolites. den Besten, C., Smink, M.C., de Vries, E.J., van Bladeren, P.J. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  13. Transfer of lindane and pentachlorobenzene from mother to newborn rabbits. Pompa, G., Fadini, L., Di Lauro, F., Caloni, F. Pharmacol. Toxicol. (1994) [Pubmed]
  14. Acute and subchronic toxicity of pentachlorobenzene. Linder, R., Scotti, T., Goldstein, J., McElroy, K., Walsh, D. Journal of environmental pathology and toxicology. (1980) [Pubmed]
  15. Metabolism and pharmacokinetics of pentachlorobenzene in the rhesus monkey. Rozman, K., Williams, J., Mueller, W.F., Coulston, F., Korte, F. Bulletin of environmental contamination and toxicology. (1979) [Pubmed]
  16. Local popliteal lymph node reactions to hexachlorobenzene and pentachlorobenzene: comparison with systemic effects. Schielen, P., Van Der Pijl, A., Bleumink, R., Pieters, R.H., Seinen, W. Immunopharmacology (1996) [Pubmed]
  17. The liver, kidney, and thyroid toxicity of chlorinated benzenes. den Besten, C., Vet, J.J., Besselink, H.T., Kiel, G.S., van Berkel, B.J., Beems, R., van Bladeren, P.J. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  18. Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. Ou, Y.C., Conolly, R.B., Thomas, R.S., Gustafson, D.L., Long, M.E., Dobrev, I.D., Chubb, L.S., Xu, Y., Lapidot, S.A., Andersen, M.E., Yang, R.S. Toxicol. Sci. (2003) [Pubmed]
  19. A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator. Thomas, R.S., Conolly, R.B., Gustafson, D.L., Long, M.E., Benjamin, S.A., Yang, R.S. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  20. Meconium and neurotoxicants: searching for a prenatal exposure timing. Ortega García, J.A., Carrizo Gallardo, D., Ferris i Tortajada, J., García, M.M., Grimalt, J.O. Arch. Dis. Child. (2006) [Pubmed]
  21. Allometry in the uptake of hydrophobic chemicals determined in vivo and in isolated perfused gills. Sijm, D.T., Verberne, M.E., de Jonge, W.J., Pärt, P., Opperhuizen, A. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
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