The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Butanen     butane

Synonyms: Diethyl, BUTANE, Butani, butan, n-Butane, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of LPG

 

Psychiatry related information on LPG

 

High impact information on LPG

  • Here we report that, under conditions favouring the H-form extrusion, guanines of the 3' half of the purine strand are protected against alkylation by dimethylsulphate, whereas adenines of the 5' half of the purine strand react with diethyl pyrocarbonate [9].
  • Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions [10].
  • Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups [1].
  • When PMN pretreated with 2-cyclohexene-1-one or diethyl maleate were incubated with formyl-methionyl-leucyl-phenylalanine (FMLP) or the proteolytic fragment of the fifth component membrane of complement, C5a, agents that interact with surface membrane receptors, increases in all five parameters were inhibited in a dose-dependent manner [11].
  • These ethanol-induced alterations were attenuated by an inhibitor of alcohol dehydrogenase and an intracellular oxidant scavenger, whereas they were enhanced by diethyl maleic acid, a glutathione depletor [12].
 

Chemical compound and disease context of LPG

 

Biological context of LPG

  • Two patients with acute severe asthma who had failed to improve with conventional treatment, mechanical ventilation, and halothane showed prompt bronchodilator response following administration of diethyl ether by inhalation [18].
  • During the course of experiments with larvae of Trichosia pubescens, we have unexpectedly found that diethyl ether or chloroform anesthesia induces a large puff in a specific band in the polytene chromosomes of the salivary glands [19].
  • We report that purines (A greater than G) in the first and/or fourth base-pair positions of occupied echinomycin-binding sites are hyperreactive to diethyl pyrocarbonate [20].
  • In addition, a class of extragenic suppressor mutations exists that suppresses some altered sensitivities but specifically does not suppress the altered sensitivity to diethyl ether [21].
  • Using in vitro chemical probing strategies, we also show that the GAA triplet repeat adopts an unusual DNA structure, demonstrated by hyperreactivity to osmium tetroxide, hydroxylamine, and diethyl pyrocarbonate [22].
 

Anatomical context of LPG

  • The treatment with diethyl ether or chloroform does not induce puffing in the polytene cells of malpighian tubules and of midgut [19].
  • Diethyl pyrocarbonate treatment produced a dose-related inhibition of specific [3H]diazepam binding to rat brain membranes with a maximal inhibition of approximately 40% at 1 mM [23].
  • Gel retardation assays combined with DNase I footprinting and diethyl pyrocarbonate interference showed that a nuclear factor from differentiated C2 myotubes and BC3H1 myocytes recognized a conserved A + T-rich sequence within the peripheral activating region [24].
  • The ubiquitin conjugating activity of crude and diethyl aminoethyl-fractionated liver cytosols of ethanol-fed rats had equal capacities to those from controls in catalyzing the formation of ubiquitin-protein conjugates [25].
  • Rats were fitted with bile duct and jugular vein catheters while anesthetized with diethyl ether, ketamine or pentobarbital [26].
 

Associations of LPG with other chemical compounds

 

Gene context of LPG

 

Analytical, diagnostic and therapeutic context of LPG

References

  1. Reversible chemical modification of the scrapie agent. McKinley, M.P., Masiarz, F.R., Prusiner, S.B. Science (1981) [Pubmed]
  2. Application of diethyl ether to Herpes simplex lesions. Mintun, H.D. JAMA (1978) [Pubmed]
  3. Cholelitholysis using methyl tertiary butyl ether. Allen, M.J., Borody, T.J., Bugliosi, T.F., May, G.R., LaRusso, N.F., Thistle, J.L. Gastroenterology (1985) [Pubmed]
  4. Redox manipulation using the thiol-oxidizing agent diethyl maleate prevents hepatocellular necrosis and apoptosis in a rodent endotoxemia model. Jones, J.J., Fan, J., Nathens, A.B., Kapus, A., Shekhman, M., Marshall, J.C., Parodo, J., Rotstein, O.D. Hepatology (1999) [Pubmed]
  5. Structure-function relationships of sea anemone toxin II from Anemonia sulcata. Barhanin, J., Hugues, M., Schweitz, H., Vincent, J.P., Lazdunski, M. J. Biol. Chem. (1981) [Pubmed]
  6. Oxidation of steroidal 5-en-3 beta-ols with Jones reagent in ether. Solaja, B.A., Milić, D.R., Dosen-Mićović, L.I. Steroids (1994) [Pubmed]
  7. Low doses of accumbens dopamine modulate amygdala suppression of spontaneous exploratory activity in rats. Yim, C.Y., Mogenson, G.J. Brain Res. (1989) [Pubmed]
  8. Anticonvulsant activity of antagonists for the NMDA-associated glycine binding site. Nichols, A.C., Yielding, K.L. Mol. Chem. Neuropathol. (1993) [Pubmed]
  9. Chemical probing of homopurine-homopyrimidine mirror repeats in supercoiled DNA. Voloshin, O.N., Mirkin, S.M., Lyamichev, V.I., Belotserkovskii, B.P., Frank-Kamenetskii, M.D. Nature (1988) [Pubmed]
  10. Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione. Bump, E.A., Yu, N.Y., Brown, J.M. Science (1982) [Pubmed]
  11. Inhibition of human polymorphonuclear leukocyte function by 2-cyclohexene-1-one. A role for glutathione in cell activation. Wedner, H.J., Simchowitz, L., Stenson, W.F., Fischman, C.M. J. Clin. Invest. (1981) [Pubmed]
  12. Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol. Kurose, I., Higuchi, H., Kato, S., Miura, S., Watanabe, N., Kamegaya, Y., Tomita, K., Takaishi, M., Horie, Y., Fukuda, M., Mizukami, K., Ishii, H. Gastroenterology (1997) [Pubmed]
  13. A single histidine is required for activity of cytochrome c peroxidase from Paracoccus denitrificans. McGinnity, D.F., Devreese, B., Prazeres, S., Van Beeumen, J., Moura, I., Moura, J.J., Pettigrew, G.W. J. Biol. Chem. (1996) [Pubmed]
  14. Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin. Wang, Y., Qiao, M., Mieyal, J.J., Asmis, L.M., Asmis, R. Free Radic. Biol. Med. (2006) [Pubmed]
  15. New perspectives on the cardioprotective phosphonate effect of the spin trap 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: an hemodynamic and 31P NMR study in rat hearts. Maurelli, E., Culcasi, M., Delmas-Beauvieux, M.C., Miollan, M., Gallis, J.L., Tron, T., Pietri, S. Free Radic. Biol. Med. (1999) [Pubmed]
  16. Inhibitors of neutral cholesteryl ester hydrolase. Harrison, E.H., Bernard, D.W., Scholm, P., Quinn, D.M., Rothblat, G.H., Glick, J.M. J. Lipid Res. (1990) [Pubmed]
  17. Gamma interferon production by hepatic NK T cells during Escherichia coli infection is resistant to the inhibitory effects of oxidative stress. Zhang, G., Nichols, R.D., Taniguchi, M., Nakayama, T., Parmely, M.J. Infect. Immun. (2003) [Pubmed]
  18. Use of ether in life-threatening acute severe asthma. Robertson, C.E., Steedman, D., Sinclair, C.J., Brown, D., Malcolm-Smith, N. Lancet (1985) [Pubmed]
  19. Experimental induction of gene activity in the salivary gland chromosomes of Trichosia pubescens (Diptera: Sciaridae). Amabis, J.M., Janczur, C. J. Cell Biol. (1978) [Pubmed]
  20. Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA. Mendel, D., Dervan, P.B. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  21. Multiple sites of action of volatile anesthetics in Caenorhabditis elegans. Morgan, P.G., Sedensky, M., Meneely, P.M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  22. The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure. Bidichandani, S.I., Ashizawa, T., Patel, P.I. Am. J. Hum. Genet. (1998) [Pubmed]
  23. Histidine modification with diethyl pyrocarbonate shows heterogeneity of benzodiazepine receptors. Burch, T.P., Ticku, M.K. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  24. A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. Gossett, L.A., Kelvin, D.J., Sternberg, E.A., Olson, E.N. Mol. Cell. Biol. (1989) [Pubmed]
  25. Effects of ethanol administration on components of the ubiquitin proteolytic pathway in rat liver. Born, L.J., Kharbanda, K.K., McVicker, D.L., Zetterman, R.K., Donohue, T.M. Hepatology (1996) [Pubmed]
  26. Effects of anesthetic agents on bile pigment excretion in the rat. Gourley, G.R., Mogilevsky, W., Arend, R.A., Siegel, F.L., Odell, G.B. Hepatology (1985) [Pubmed]
  27. Modular recognition of 5-base-pair DNA sequence motifs by human heat shock transcription factor. Cunniff, N.F., Wagner, J., Morgan, W.D. Mol. Cell. Biol. (1991) [Pubmed]
  28. The autoinhibition of sorghum NADP malate dehydrogenase is mediated by a C-terminal negative charge. Ruelland, E., Johansson, K., Decottignies, P., Djukic, N., Miginiac-Maslow, M. J. Biol. Chem. (1998) [Pubmed]
  29. Platelet-activating factor stimulation of rabbit platelets is blocked by serine protease inhibitor (chymotryptic protease inhibitor). Sugatani, J., Miwa, M., Hanahan, D.J. J. Biol. Chem. (1987) [Pubmed]
  30. Intramolecular DNA triplexes in supercoiled plasmids. I. Effect of loop size on formation and stability. Shimizu, M., Hanvey, J.C., Wells, R.D. J. Biol. Chem. (1989) [Pubmed]
  31. Expression and purification of two isozymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification. Busby, R.W., Chang, M.D., Busby, R.C., Wimp, J., Townsend, C.A. J. Biol. Chem. (1995) [Pubmed]
  32. The peroxisome proliferator-induced cytosolic type I acyl-CoA thioesterase (CTE-I) is a serine-histidine-aspartic acid alpha /beta hydrolase. Huhtinen, K., O'Byrne, J., Lindquist, P.J., Contreras, J.A., Alexson, S.E. J. Biol. Chem. (2002) [Pubmed]
  33. Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. Meyers, M.J., Sun, J., Carlson, K.E., Katzenellenbogen, B.S., Katzenellenbogen, J.A. J. Med. Chem. (1999) [Pubmed]
  34. Induction of metallothionein by diethyl maleate. Bauman, J.W., McKim, J.M., Liu, J., Klaassen, C.D. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  35. Fate and role of peroxisomes during the life cycle of the yeast Saccharomyces cerevisiae: inheritance of peroxisomes during meiosis. Gurvitz, A., Rottensteiner, H., Hamilton, B., Ruis, H., Hartig, A., Dawes, I.W., Binder, M. Histochem. Cell Biol. (1998) [Pubmed]
  36. Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation. Cho, K.H., An, S., Lee, W.S., Paik, Y.K., Kim, Y.K., Jeong, T.S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  37. Modification of histidine 56 in adrenodoxin with diethyl pyrocarbonate inhibited the interaction with cytochrome P-450scc and adrenodoxin reductase. Miura, S., Tomita, S., Ichikawa, Y. J. Biol. Chem. (1991) [Pubmed]
  38. Circular dichroism studies of diethyl pyrocarbonate-modified histidine in hen egg white lysozyme. Li, C., Moore, D.S., Rosenberg, R.C. J. Biol. Chem. (1993) [Pubmed]
  39. Characterization of histidine residues essential for receptor binding and activity of nerve growth factor. Woo, S.B., Neet, K.E. J. Biol. Chem. (1996) [Pubmed]
  40. Sequences near the origin of replication of the DHFR locus of Chinese hamster ovary cells adopt left-handed Z-DNA and triplex structures. Bianchi, A., Wells, R.D., Heintz, N.H., Caddle, M.S. J. Biol. Chem. (1990) [Pubmed]
  41. Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa. Boughton-Smith, N.K., Hawkey, C.J., Whittle, B.J. Gut (1983) [Pubmed]
 
WikiGenes - Universities