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Nakase, T. et al.

Nakase, Ariga, Yonenobu, Tsumaki, Luyten, Mukai, Sato, Yoshikawa,

Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum.

Localization and expression of cartilage-derived morphogenetic protein (CDMP)-1 in tissues at the site of ossification of the ligamentum flavum (OLF) were examined by immunohistochemistry and in situ hybridization. The CDMP-1 protein and messenger ribonucleic acid (mRNA) were localized in spindle-shaped cells and chondrocytes in the OLF tissues. CDMP-1 was not detected in cells in non-ossified sites. These data indicate that CDMP-1 is locally activated and localized in spindle-shaped cells and chondrocytes at the site of OLE. Given the previously reported promoting action of CDMP-1 for chondrogenesis, the current results suggest that CDMP-1 may be involved in the progression of OLF, leading to the narrowing of spinal canal and thus causing severe clinical manifestations.[1]

References

Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum. Nakase, T., Ariga, K., Yonenobu, K., Tsumaki, N., Luyten, F.P., Mukai, Y., Sato, I., Yoshikawa, H. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. (2001) [Pubmed]

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