Approaches to gene therapy with sodium/iodide symporter.
Since cloning and characterization of the sodium iodide symporter ( NIS) gene, several investigators explored the possibility of a novel cytoreductive gene therapy strategy based on NIS gene transfer into non-thyroidal tumor cells followed by radioiodine therapy. NIS gene transfer has been shown to be capable of inducing radioiodine accumulation in vitro and in vivo in several non-thyroidal cancer cell lines. Following PSA promoter- mediated NIS gene delivery we were able to demonstrate prostate-specific iodide accumulation in prostate cancer cells that was high enough to elicit a therapeutic response of 131-I in vitro and in vivo. This study clearly demonstrates the potential of NIS as a novel therapeutic gene for non-thyroidal cancers, in particular prostate cancer.[1]References
- Approaches to gene therapy with sodium/iodide symporter. Spitzweg, C., Morris, J.C. Exp. Clin. Endocrinol. Diabetes (2001) [Pubmed]
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