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Chemical Compound Review

sodium iodide     sodium iodide

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Disease relevance of sodium iodide


High impact information on sodium iodide

  • Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology [5].
  • The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance [6].
  • CONTEXT: In May 1997, the US Nuclear Regulatory Commission (NRC) revised its patient release regulations, allowing for outpatient administration of larger activities of sodium iodide 131I than previously permitted [7].
  • The results reported here show that in the absence of either TSH or a functional TSHR, the thyroid gland develops to a normal size, whereas the expression of thyroperoxidase and the sodium/iodide symporter are reduced greatly [8].
  • We demonstrate that the reintroduction of Pax8 in PCPy cells is sufficient to activate expression of the endogenous genes encoding thyroglobulin, thyroperoxidase, and sodium/iodide symporter [9].

Chemical compound and disease context of sodium iodide


Biological context of sodium iodide


Anatomical context of sodium iodide


Associations of sodium iodide with other chemical compounds


Gene context of sodium iodide

  • Cytokine-activated PMNLs expressed functional CCR6, as detected by the binding of sodium iodide I 125-labeled liver and activation-regulated chemokine (LARC) and dose-dependent migration toward LARC [27].
  • The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene [15].
  • Type I interferons modulate the expression of thyroid peroxidase, sodium/iodide symporter, and thyroglobulin genes in primary human thyrocyte cultures [28].
  • In hypofunctioning adenomas, LNOX immunostaining was highly variable among follicles, whereas sodium/iodide (Na+/I-) symporter immunostaining was decreased [29].
  • Increased intracellular iodide concentration is mediated by IgG, which activates the upstream enhancer of the sodium/iodide symporter (NIS) [30].

Analytical, diagnostic and therapeutic context of sodium iodide


  1. The mammary gland iodide transporter is expressed during lactation and in breast cancer. Tazebay, U.H., Wapnir, I.L., Levy, O., Dohan, O., Zuckier, L.S., Zhao, Q.H., Deng, H.F., Amenta, P.S., Fineberg, S., Pestell, R.G., Carrasco, N. Nat. Med. (2000) [Pubmed]
  2. Effect on exophthalmos of various methods of treatment of Graves' disease. Gwinup, G., Elias, A.N., Ascher, M.S. JAMA (1982) [Pubmed]
  3. Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas. Saito, T., Endo, T., Kawaguchi, A., Ikeda, M., Katoh, R., Kawaoi, A., Muramatsu, A., Onaya, T. J. Clin. Invest. (1998) [Pubmed]
  4. Congenital hypothyroidism due to mutations in the sodium/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3' splice site. Pohlenz, J., Rosenthal, I.M., Weiss, R.E., Jhiang, S.M., Burant, C., Refetoff, S. J. Clin. Invest. (1998) [Pubmed]
  5. Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. De La Vieja, A., Dohan, O., Levy, O., Carrasco, N. Physiol. Rev. (2000) [Pubmed]
  6. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Dohán, O., De la Vieja, A., Paroder, V., Riedel, C., Artani, M., Reed, M., Ginter, C.S., Carrasco, N. Endocr. Rev. (2003) [Pubmed]
  7. Radiation exposure from outpatient radioactive iodine (131I) therapy for thyroid carcinoma. Grigsby, P.W., Siegel, B.A., Baker, S., Eichling, J.O. JAMA (2000) [Pubmed]
  8. Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. Postiglione, M.P., Parlato, R., Rodriguez-Mallon, A., Rosica, A., Mithbaokar, P., Maresca, M., Marians, R.C., Davies, T.F., Zannini, M.S., De Felice, M., Di Lauro, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Pax8 has a key role in thyroid cell differentiation. Pasca di Magliano, M., Di Lauro, R., Zannini, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  10. Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer models. Kogai, T., Kanamoto, Y., Che, L.H., Taki, K., Moatamed, F., Schultz, J.J., Brent, G.A. Cancer Res. (2004) [Pubmed]
  11. Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. Knostman, K.A., Cho, J.Y., Ryu, K.Y., Lin, X., McCubrey, J.A., Hla, T., Liu, C.H., Di Carlo, E., Keri, R., Zhang, M., Hwang, D.Y., Kisseberth, W.C., Capen, C.C., Jhiang, S.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  12. Dexamethasone stimulation of retinoic Acid-induced sodium iodide symporter expression and cytotoxicity of 131-I in breast cancer cells. Unterholzner, S., Willhauck, M.J., Cengic, N., Schütz, M., Göke, B., Morris, J.C., Spitzweg, C. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  13. Virucidal effects of glucose oxidase and peroxidase or their protein conjugates on human immunodeficiency virus type 1. Yamaguchi, Y., Semmel, M., Stanislawski, L., Strosberg, A.D., Stanislawski, M. Antimicrob. Agents Chemother. (1993) [Pubmed]
  14. Lung cancer detection using a miniature sodium iodide detector and cobalt-57 bleomycin. Woolfenden, J.M., Nevin, W.S., Barber, H.B., Donahue, D.J. Chest (1984) [Pubmed]
  15. The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene. Costamagna, E., García, B., Santisteban, P. J. Biol. Chem. (2004) [Pubmed]
  16. The CRE-like element inside the 5'-upstream region of the rat sodium/iodide symporter gene interacts with diverse classes of b-Zip molecules that regulate transcriptional activities through strong synergy with Pax-8. Chun, J.T., Di Dato, V., D'Andrea, B., Zannini, M., Di Lauro, R. Mol. Endocrinol. (2004) [Pubmed]
  17. Radiotracer diffusion and ionic conduction in a PEO-NaI polymer electrolyte. Stolwijk, N.A., Obeidi, S.h. Phys. Rev. Lett. (2004) [Pubmed]
  18. Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells. Ludgate, M., Gire, V., Crisp, M., Ajjan, R., Weetman, A., Ivan, M., Wynford-Thomas, D. Oncogene (1999) [Pubmed]
  19. Expression of the thyroid sodium/iodide symporter in Xenopus laevis oocytes. Vilijn, F., Carrasco, N. J. Biol. Chem. (1989) [Pubmed]
  20. Regulation of iodide uptake and sodium/iodide symporter expression in the mcf-7 human breast cancer cell line. Arturi, F., Ferretti, E., Presta, I., Mattei, T., Scipioni, A., Scarpelli, D., Bruno, R., Lacroix, L., Tosi, E., Gulino, A., Russo, D., Filetti, S. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  21. A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect. Kosugi, S., Bhayana, S., Dean, H.J. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  22. The role of cytochrome c4 in bacterial respiration. Cellular location and selective removal from membranes. Hunter, D.J., Brown, K.R., Pettigrew, G.W. Biochem. J. (1989) [Pubmed]
  23. Three-dimensional organization of thyroid cells into follicle structures is a pivotal factor in the control of sodium/iodide symporter expression. Bernier-Valentin, F., Trouttet-Masson, S., Rabilloud, R., Selmi-Ruby, S., Rousset, B. Endocrinology (2006) [Pubmed]
  24. Chemically modified bovine prothrombin as a substrate in studies of activation kinetics and fluorescence changes during thrombin formation. Silverberg, S.A. J. Biol. Chem. (1980) [Pubmed]
  25. Studies of HLA-DR expression on cultured human thyrocytes: effect of antithyroid drugs and other agents on interferon-gamma-induced HLA-DR expression. Aguayo, J., Iitaka, M., Row, V.V., Volpé, R. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  26. The inception of photoelectric scintillation detection commemorated after three decades. Hine, G.J. J. Nucl. Med. (1977) [Pubmed]
  27. Expression of CCR6 and CD83 by cytokine-activated human neutrophils. Yamashiro, S., Wang, J.M., Yang, D., Gong, W.H., Kamohara, H., Yoshimura, T. Blood (2000) [Pubmed]
  28. Type I interferons modulate the expression of thyroid peroxidase, sodium/iodide symporter, and thyroglobulin genes in primary human thyrocyte cultures. Caraccio, N., Giannini, R., Cuccato, S., Faviana, P., Berti, P., Galleri, D., Dardano, A., Basolo, F., Ferrannini, E., Monzani, F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  29. Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues. Caillou, B., Dupuy, C., Lacroix, L., Nocera, M., Talbot, M., Ohayon, R., Dème, D., Bidart, J.M., Schlumberger, M., Virion, A. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  30. The current status of radioiodine therapy for benign thyroid disorders. van Isselt, J.W., van Dongen, A.J. Hellenic journal of nuclear medicine. (2004) [Pubmed]
  31. Radioisotope concentrator gene therapy using the sodium/iodide symporter gene. Mandell, R.B., Mandell, L.Z., Link, C.J. Cancer Res. (1999) [Pubmed]
  32. Adenovirus-mediated transfer of the thyroid sodium/iodide symporter gene into tumors for a targeted radiotherapy. Boland, A., Ricard, M., Opolon, P., Bidart, J.M., Yeh, P., Filetti, S., Schlumberger, M., Perricaudet, M. Cancer Res. (2000) [Pubmed]
  33. Treatment of hyperthyroidism with a large initial dose of sodium iodide I 131. Safa, A.M., Skillern, P.G. Arch. Intern. Med. (1975) [Pubmed]
  34. Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene. Groot-Wassink, T., Aboagye, E.O., Glaser, M., Lemoine, N.R., Vassaux, G. Hum. Gene Ther. (2002) [Pubmed]
  35. A preclinical large animal model of adenovirus-mediated expression of the sodium-iodide symporter for radioiodide imaging and therapy of locally recurrent prostate cancer. Dwyer, R.M., Schatz, S.M., Bergert, E.R., Myers, R.M., Harvey, M.E., Classic, K.L., Blanco, M.C., Frisk, C.S., Marler, R.J., Davis, B.J., O'Connor, M.K., Russell, S.J., Morris, J.C. Mol. Ther. (2005) [Pubmed]
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