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Chemical Compound Review

Iodide-123     iodide

Synonyms: CHEMBL1249, iodine-123(1-), I-123, AC1L366B, 69239-56-1, ...
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Disease relevance of iodide


Psychiatry related information on iodide


High impact information on iodide


Chemical compound and disease context of iodide


Biological context of iodide

  • The known occurrence of methyl iodide in natural waters and our demonstration that Me4Pb is readily synthesized from this reagent and Pb(II) salts in aqueous solution could have far reaching significance not only for the chemical synthesis of toxic organoleads but also for possible mechanisms of microbiological methylation [20].
  • In vivo injection of fluorochromes such as 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide; 3,3'dihexyloxacarbocyanine iodide; or HE allows for the detection of cells that are programmed for death but still lack nuclear DNA fragmentation [21].
  • Iodination of cells in suspension results in lactoperoxidase-specific iodide incorporation with no loss of cell viability under the conditions employed, less than 3% lipid labeling, and more than 90% of the labeled species identifiable as monoiodotyrosine [22].
  • The kinetics of binding of [3H]acetylcholine in the presence and absence of 30 micron carbamoylcholine to occupy acetylcholine binding sites, [14C]-meproadifen [2-(diethylmethylaminoethyl)-2,2-diphenylvalerate iodide ] was bound with a dissociation constant, KD, of 0.3 +/- 0.1 micron to 0.3 +/- 0.1 site per [3H]alpha-toxin site [23].
  • By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine++ + iodide (JC-1), we find that membrane potentials across mitochondria in a living cell can be heterogeneous [24].

Anatomical context of iodide

  • The isolated plasma membrane was recovered in high yield (28%) and enriched 30-fold in terms of incorporated iodide [25].
  • Mast cells, when supplemented with H2O2 and iodide, are cytotoxic to mammalian tumor cells as determined by 51Cr release, and transmission and scanning electron microscopy [26].
  • The generation of these oxidants is linear with neutrophil concentration, favored at alkaline pH, and inhibited by supraphysiologic concentrations of iodide or bromide [27].
  • To identify small-molecule correctors of defective cellular processing, we assayed iodide flux in DeltaF508-CFTR-transfected epithelial cells using a fluorescent halide indicator [28].
  • We examined planar sections stained for VIP by the avidin-biotin complex method, measured VIP content in mucosa and muscularis propria by radioimmunoassay, and compared neural structures reactive to VIP antiserum with those revealed by osmication in the presence of zinc iodide [29].

Associations of iodide with other chemical compounds


Gene context of iodide


Analytical, diagnostic and therapeutic context of iodide


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  2. The mammary gland iodide transporter is expressed during lactation and in breast cancer. Tazebay, U.H., Wapnir, I.L., Levy, O., Dohan, O., Zuckier, L.S., Zhao, Q.H., Deng, H.F., Amenta, P.S., Fineberg, S., Pestell, R.G., Carrasco, N. Nat. Med. (2000) [Pubmed]
  3. Congenital goiter with defective iodide transport. Wolff, J. Endocr. Rev. (1983) [Pubmed]
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  5. Prooxidant activity of transferrin and lactoferrin. Klebanoff, S.J., Waltersdorph, A.M. J. Exp. Med. (1990) [Pubmed]
  6. Highly selective iodide poly(vinyl chloride) membrane electrode based on a nickel(II) tetraazaannulene macrocyclic complex. Ying, M., Yuan, R., Zhang, X.M., Song, Y.Q., Li, Z.Q., Shen, G.L., Yu, R.Q. The Analyst. (1997) [Pubmed]
  7. Electroconvulsive therapy and the chronic use of pseudocholinesterase-inhibitor (echothiophate iodide) eye drops for glaucoma. A case report. Messer, G.J., Stoudemire, A., Knos, G., Johnson, G.C. General hospital psychiatry. (1992) [Pubmed]
  8. Iodide-induced hypothyroidism in a patient with anorexia nervosa. Haraguchi, K., Aida, K., Akasu, F., Takazawa, K., Onaya, T. Endocrinol. Jpn. (1986) [Pubmed]
  9. Alterations of antioxidant tissue defense enzymes and related metabolic parameters in streptozotocin-diabetic rats--effects of iodine treatment. Winkler, R., Moser, M. Wien. Klin. Wochenschr. (1992) [Pubmed]
  10. Peroxidase-catalyzed halogenation. Morrison, M., Schonbaum, G.R. Annu. Rev. Biochem. (1976) [Pubmed]
  11. Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. De La Vieja, A., Dohan, O., Levy, O., Carrasco, N. Physiol. Rev. (2000) [Pubmed]
  12. Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore. Crowley, K.S., Liao, S., Worrell, V.E., Reinhart, G.D., Johnson, A.E. Cell (1994) [Pubmed]
  13. Suppression of thyroid radioiodine uptake by various doses of stable iodide. Sternthal, E., Lipworth, L., Stanley, B., Abreau, C., Fang, S.L., Braverman, L.E. N. Engl. J. Med. (1980) [Pubmed]
  14. Iodide and negative anion gap. Fischman, R.A., Fairclough, G.F., Cheigh, J.S. N. Engl. J. Med. (1978) [Pubmed]
  15. Prostaglandin E2 modulates neurally induced nonadrenergic, noncholinergic gastric relaxations in the rabbit in vivo. Baccari, M.C., Calamai, F., Staderini, G. Gastroenterology (1996) [Pubmed]
  16. Methyl iodide toxicity. Appel, G.B. Ann. Intern. Med. (1977) [Pubmed]
  17. Partial and total iodide organification defect in different sibships in a kindred. Perez-Cuvit, E., Crigler, J.F., Stanbury, J.B. Am. J. Hum. Genet. (1977) [Pubmed]
  18. Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line. Kogai, T., Schultz, J.J., Johnson, L.S., Huang, M., Brent, G.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  19. Genetically targeted radiotherapy for multiple myeloma. Dingli, D., Diaz, R.M., Bergert, E.R., O'Connor, M.K., Morris, J.C., Russell, S.J. Blood (2003) [Pubmed]
  20. Chemical alkylation of lead (II) salts to tetraalkyllead (IV) in aqueous solution. Ahmad, I., Chau, Y.K., Wong, P.T., Carty, A.J., Taylor, L. Nature (1980) [Pubmed]
  21. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S.A., Petit, P.X., Mignotte, B., Kroemer, G. J. Exp. Med. (1995) [Pubmed]
  22. Externally disposed plasma membrane proteins. I. Enzymatic iodination of mouse L cells. Hubbard, A.L., Cohn, Z.A. J. Cell Biol. (1975) [Pubmed]
  23. Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides. Neubig, R.R., Krodel, E.K., Boyd, N.D., Cohen, J.B. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  24. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Smiley, S.T., Reers, M., Mottola-Hartshorn, C., Lin, M., Chen, A., Smith, T.W., Steele, G.D., Chen, L.B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  25. Plasma membrane of Entamoeba histolytica. Aley, S.B., Scott, W.A., Cohn, Z.A. J. Exp. Med. (1980) [Pubmed]
  26. Mast cell-mediated tumor-cell cytotoxicity. Role of the peroxidase system. Henderson, W.R., Chi, E.Y., Jong, E.C., Klebanoff, S.J. J. Exp. Med. (1981) [Pubmed]
  27. Generation of nitrogen-chlorine oxidants by human phagocytes. Test, S.T., Lampert, M.B., Ossanna, P.J., Thoene, J.G., Weiss, S.J. J. Clin. Invest. (1984) [Pubmed]
  28. Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. Pedemonte, N., Lukacs, G.L., Du, K., Caci, E., Zegarra-Moran, O., Galietta, L.J., Verkman, A.S. J. Clin. Invest. (2005) [Pubmed]
  29. Distribution of vasoactive intestinal polypeptide-immunoreactive structures in the opossum esophagus. Christensen, J., Williams, T.H., Jew, J., O'Dorisio, T.M. Gastroenterology (1987) [Pubmed]
  30. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Anderson, M.P., Gregory, R.J., Thompson, S., Souza, D.W., Paul, S., Mulligan, R.C., Smith, A.E., Welsh, M.J. Science (1991) [Pubmed]
  31. Perchlorate and the thyroid gland. Wolff, J. Pharmacol. Rev. (1998) [Pubmed]
  32. Iodide-induced hypothyroidism: a potential hazard during perinatal life. Theodoropoulos, T., Braverman, L.E., Vagenakis, A.G. Science (1979) [Pubmed]
  33. Acetylthiocholine iodide for detecting acetylcholinesterase activity in amniotic fluid. Holman, M.S., Knight, G.J., Haddow, J.E. Lancet (1980) [Pubmed]
  34. Autoregulation of thyroid-specific gene transcription by thyroglobulin. Suzuki, K., Lavaroni, S., Mori, A., Ohta, M., Saito, J., Pietrarelli, M., Singer, D.S., Kimura, S., Katoh, R., Kawaoi, A., Kohn, L.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  35. Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. Postiglione, M.P., Parlato, R., Rodriguez-Mallon, A., Rosica, A., Mithbaokar, P., Maresca, M., Marians, R.C., Davies, T.F., Zannini, M.S., De Felice, M., Di Lauro, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  36. Carbonic anhydrase II deficiency: diagnosis and carrier detection using differential enzyme inhibition and inactivation. Sundaram, V., Rumbolo, P., Grubb, J., Strisciuglio, P., Sly, W.S. Am. J. Hum. Genet. (1986) [Pubmed]
  37. Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Hulander, M., Kiernan, A.E., Blomqvist, S.R., Carlsson, P., Samuelsson, E.J., Johansson, B.R., Steel, K.P., Enerbäck, S. Development (2003) [Pubmed]
  38. Regulation of the cystic fibrosis transmembrane conductance regulator channel by beta-adrenergic agonists and vasoactive intestinal peptide in rat smooth muscle cells and its role in vasorelaxation. Robert, R., Thoreau, V., Norez, C., Cantereau, A., Kitzis, A., Mettey, Y., Rogier, C., Becq, F. J. Biol. Chem. (2004) [Pubmed]
  39. Oxygen activation and reduction in respiration: involvement of redox-active tyrosine 244. Proshlyakov, D.A., Pressler, M.A., DeMaso, C., Leykam, J.F., DeWitt, D.L., Babcock, G.T. Science (2000) [Pubmed]
  40. Accumulation of plasma triiodothyronine sulfate in rats treated with propylthiouracil. Rutgers, M., Bonthuis, F., de Herder, W.W., Visser, T.J. J. Clin. Invest. (1987) [Pubmed]
  41. Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. Wu, D., Yang, J., Pardridge, W.M. J. Clin. Invest. (1997) [Pubmed]
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