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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Orr, H.T.

Qs in the nucleus.

The polyglutamine diseases include at least nine neurodegenerative disorders. Accumulation of mutant protein with a toxic gain-in function in the nucleus appears to be the pathological basis of these diseases. In this issue of Neuron, La Spada et al. (2001) provide insight into the cell specificity of pathology for a polyglutamine disease by relating SCA7- induced retinal degeneration to a disruption of the photoreceptor-specific transcription factor CRX.[1]

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Qs in the nucleus. Orr, H.T. Neuron (2001) [Pubmed]

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