- Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Nakagawa, H., Nuovo, G.J., Zervos, E.E., Martin, E.W., Salovaara, R., Aaltonen, L.A., de la Chapelle, A. Cancer Res. (2001)