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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Study of different coupling agents in the conjugation of a V3-based synthetic MAP to carrier proteins.

The conjugation of synthetic peptides to carrier proteins is a widely used method for immunological studies. Different coupling agents have been described to form the conjugate with carrier proteins. In this paper, we demonstrate that the antibody response toward V3-based synthetic MAPs derived from HIV-1, JY1 isolate, conjugated to two different carrier proteins using either m-maleimidobenzoyl-N-hydroxysuccinimide ester ( MBS) or beta-maleimidopropionic acid N-hydroxysuccinimide ester (MPS), or succinic anhydride (SA) show different behaviors. An excellent anti-JY1 response without a strong response to the coupling agent is observed in the case of succinic anhydride spacer. In contrast, MBS produces total abrogation of the antibody response with a high response toward the coupling agent.[1]

References

  1. Study of different coupling agents in the conjugation of a V3-based synthetic MAP to carrier proteins. Cruz, L.J., Iglesias, E., Aguilar, J.C., Quintana, D., Garay, H.E., Duarte, C., Reyes, O. J. Pept. Sci. (2001) [Pubmed]
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