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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A characteristic effect of hallucinogens on investigatory responding in rats.

The disruption of the temporal distribution of investigatory responses by rats in a novel hole-board following lysergic acid diethylamide-25 (LSD), as described in a companion paper (Geyer and Light, 1979), was found to be a characteristic effect of a variety of hallucinogens. Similar effects were produced by indoleamine hallucinogens, such as LSD, N,N-dimethyltryptamine, and psilocin, and by phenylethylamine hallucinogens, such as mescaline or 2,5-dimethoxy-4-methylamphetamine ( DOM). Congeners of DOM that are inactive in humans had no significant effects. Furthermore, of a variety of other psychoactive drugs tested, only apomorphine produced an effect similar to that of the hallucinogens. These results suggest that a simple behavioral measure of exploration in a hole-board may provide a useful animal model with which to examine the common effects of hallucinogens.[1]


  1. A characteristic effect of hallucinogens on investigatory responding in rats. Geyer, M.A., Light, R.K., Rose, G.J., Petersen, L.R., Horwitt, D.D., Adams, L.M., Hawkins, R.L. Psychopharmacology (Berl.) (1979) [Pubmed]
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