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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells.

Mutants resistant to 6-thioguanine were induced in pseudotetraploid hybrid Chinese hamster cells homozygous wild-type at the locus for hypoxanthine phophoribosyl transferase but heterozygous for the linked marker glucose-6-phosphate dehydrogenase. About half of these mutants had concomitantly lost the wild-type allele for glucose-6-phosphate dehydrogenase, as expected if mutation plus chromosome segregation had occurred.[1]


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