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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells.

Mutants resistant to 6-thioguanine were induced in pseudotetraploid hybrid Chinese hamster cells homozygous wild-type at the locus for hypoxanthine phophoribosyl transferase but heterozygous for the linked marker glucose-6-phosphate dehydrogenase. About half of these mutants had concomitantly lost the wild-type allele for glucose-6-phosphate dehydrogenase, as expected if mutation plus chromosome segregation had occurred.[1]

References

  1. Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells. Chasin, L.A., Urlaub, G. Science (1975) [Pubmed]
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