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Aruffo, A. et al.

Aruffo, Hollenbaugh,

Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease.

Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are now in late-stage clinical development (phase II, phase III) or have recently completed phase III clinical trials. Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD11a antibody, have shown efficacy in pivotal phase III trials in patients with plaque psoriasis. These new medicines are poised to enter clinical use in 2002.[1]

References

Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease. Aruffo, A., Hollenbaugh, D. Curr. Opin. Immunol. (2001) [Pubmed]

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