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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19.

The cytochrome P450 superfamily of mixed-function oxygenases has been extensively studied due to its many critical metabolic roles, and also because it is a fascinating example of gene family evolution. The cluster of genes on human chromosome 19 from the CYP2A, 2B, and 2F subfamilies has been previously described as having a complex organization and many pseudogenes. We describe the discovery of genes from three more CYP2 subfamilies inside the cluster, and assemble a complete map of the region. We comprehensively review the organization, structure, and expression of genes from all six subfamilies. A general hypothesis for the evolution of this complex gene cluster is also presented.[1]

References

  1. Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19. Hoffman, S.M., Nelson, D.R., Keeney, D.S. Pharmacogenetics (2001) [Pubmed]
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