Gene Review:
CYP2A - cytochrome P450, family 2, subfamily A
Homo sapiens
Synonyms:
CYP1, CYP2, P450C2, P450C2A, P450PB
- Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas. Miyazaki, M., Yamazaki, H., Takeuchi, H., Saoo, K., Yokohira, M., Masumura, K., Nohmi, T., Funae, Y., Imaida, K., Kamataki, T. Carcinogenesis (2005)
- Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy. Walsh, K.V., Harley, H.G., Brook, J.D., Rundle, S.A., Sarfarazi, M., Harper, P.S., Shaw, D.J. Hum. Genet. (1990)
- Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue. Williams, J.A., Martin, F.L., Muir, G.H., Hewer, A., Grover, P.L., Phillips, D.H. Carcinogenesis (2000)
- Does selenium reduce the risk of threatened preterm delivery associated with placental cytochrome P450-1A1 activity? Huel, G., Campagna, D., Girard, F., Moreau, T., Blot, P. Environmental research. (2000)
- Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort. Chaudhary, A., Willett, K.L. Toxicology (2006)
- Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. Nebert, D.W., Dalton, T.P., Okey, A.B., Gonzalez, F.J. J. Biol. Chem. (2004)
- Near completely humanized liver in mice shows human-type metabolic responses to drugs. Tateno, C., Yoshizane, Y., Saito, N., Kataoka, M., Utoh, R., Yamasaki, C., Tachibana, A., Soeno, Y., Asahina, K., Hino, H., Asahara, T., Yokoi, T., Furukawa, T., Yoshizato, K. Am. J. Pathol. (2004)
- A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4. Chen, D., Lepar, G., Kemper, B. J. Biol. Chem. (1994)
- Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. Gotoh, O. J. Biol. Chem. (1992)
- Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk. Long, J.R., Egan, K.M., Dunning, L., Shu, X.O., Cai, Q., Cai, H., Dai, Q., Holtzman, J., Gao, Y.T., Zheng, W. Pharmacogenet. Genomics (2006)
- Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19. Hoffman, S.M., Nelson, D.R., Keeney, D.S. Pharmacogenetics (2001)
- Localization of CYP2F1 by multipoint linkage analysis and pulsed-field gel electrophoresis. Bale, A.E., Mitchell, A.L., Gonzalez, F.J., McBride, O.W. Genomics (1991)
- Polymorphisms of CYP2A6 and its practical consequences. Raunio, H., Rautio, A., Gullstén, H., Pelkonen, O. British journal of clinical pharmacology. (2001)
- Sex-dependent metabolism of xenobiotics. Mugford, C.A., Kedderis, G.L. Drug Metab. Rev. (1998)
- Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes. Miyazawa, M., Sugie, A., Shimada, T. Drug Metab. Dispos. (2003)
- Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen. Thornton-Manning, J.R., Nikula, K.J., Hotchkiss, J.A., Avila, K.J., Rohrbacher, K.D., Ding, X., Dahl, A.R. Toxicol. Appl. Pharmacol. (1997)
- Epidermal CYP2 family cytochromes P450. Du, L., Hoffman, S.M., Keeney, D.S. Toxicol. Appl. Pharmacol. (2004)
- Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism. Oscarson, M., McLellan, R.A., Gullstén, H., Agúndez, J.A., Benítez, J., Rautio, A., Raunio, H., Pelkonen, O., Ingelman-Sundberg, M. FEBS Lett. (1999)
- Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene. Fontaine, S.M., Hoyer, P.B., Halpert, J.R., Sipes, I.G. Drug Metab. Dispos. (2001)
- Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole. Diani-Moore, S., Papachristou, F., Labitzke, E., Rifkind, A.B. Drug Metab. Dispos. (2006)
- Expression of cytochromes P450 in human breast tissue and tumors. Huang, Z., Fasco, M.J., Figge, H.L., Keyomarsi, K., Kaminsky, L.S. Drug Metab. Dispos. (1996)
- Cloning and expression of cytochrome P450 genes, belonging to a new P450 family, of the basidiomycete Lentinula edodes. Akiyama, R., Sato, Y., Kajiwara, S., Shishido, K. Biosci. Biotechnol. Biochem. (2002)
- Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). Rylander, T., Neve, E.P., Ingelman-Sundberg, M., Oscarson, M. Biochem. Biophys. Res. Commun. (2001)
- Identification and cross-species comparisons of CYP2F subfamily genes in mammals. Chen, N., Whitehead, S.E., Caillat, A.W., Gavit, K., Isphording, D.R., Kovacevic, D., McCreary, M.B., Hoffman, S.M. Mutat. Res. (2002)
- Identification of a new human CYP2A gene fragment with close linkage to CYP2GP1. Sheng, J., Hua, Z., Guo, J., Caggana, M., Ding, X. Drug Metab. Dispos. (2001)
- Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. Lewis, D.F. Arch. Biochem. Biophys. (2003)