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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung.

Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma.[1]

References

  1. Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung. Thambisetty, M.R., Scherzer, C.R., Yu, Z., Lennon, V.A., Newman, N.J. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. (2001) [Pubmed]
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