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Gene Review

DPYSL5  -  dihydropyrimidinase-like 5

Homo sapiens

Synonyms: CRAM, CRMP-5, CRMP3-associated molecule, CRMP5, Collapsin response mediator protein 5, ...
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Disease relevance of DPYSL5


High impact information on DPYSL5


Biological context of DPYSL5


Anatomical context of DPYSL5


Associations of DPYSL5 with chemical compounds

  • Neuronal autoantibody specificities were, in descending order of frequency, as follows: glutamic acid decarboxylase, voltage-gated potassium channel, collapsin response-mediator protein-5, ganglionic AChR, and antineuronal nuclear antibody-type 1 (ANNA-1) [12].
  • The epoxide moiety in 1 was generated by regioselective mesylation and base treatment of the 12,13-diol 30 which was formed by a chelate Cram controlled Grignard addition of 14 and methyl ketone 13 [13].
  • A comparison was made between this new and virtually unused method and our earlier reported results using Cram methodology (reaction of aryl iodide with potassium tert-butoxide) [14].
  • Paraneoplastic autonomic disorders are clinically indistinguishable and associated with various overlapping antibody associations, including anti-Hu (ANNA-1), ganglionic acetylcholine receptors, CRMP-5, and PCA-2 [15].
  • We use molecular mechanics to calculate the conformational properties of a cyclic urea mimetic of alpha-chymotrypsin proposed, but not yet synthesized, by Cram and co-workers [16].

Other interactions of DPYSL5


Analytical, diagnostic and therapeutic context of DPYSL5


  1. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Yu, Z., Kryzer, T.J., Griesmann, G.E., Kim, K., Benarroch, E.E., Lennon, V.A. Ann. Neurol. (2001) [Pubmed]
  2. Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. Vernino, S., Tuite, P., Adler, C.H., Meschia, J.F., Boeve, B.F., Boasberg, P., Parisi, J.E., Lennon, V.A. Ann. Neurol. (2002) [Pubmed]
  3. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Hart, I.K., Maddison, P., Newsom-Davis, J., Vincent, A., Mills, K.R. Brain (2002) [Pubmed]
  4. Inflammatory transverse myelitis: evolving concepts. Pittock, S.J., Lucchinetti, C.F. Curr. Opin. Neurol. (2006) [Pubmed]
  5. Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Cross, S.A., Salomao, D.R., Parisi, J.E., Kryzer, T.J., Bradley, E.A., Mines, J.A., Lam, B.L., Lennon, V.A. Ann. Neurol. (2003) [Pubmed]
  6. Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain. Inatome, R., Tsujimura, T., Hitomi, T., Mitsui, N., Hermann, P., Kuroda, S., Yamamura, H., Yanagi, S. J. Biol. Chem. (2000) [Pubmed]
  7. Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family. Fukada, M., Watakabe, I., Yuasa-Kawada, J., Kawachi, H., Kuroiwa, A., Matsuda, Y., Noda, M. J. Biol. Chem. (2000) [Pubmed]
  8. Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain. Horiuchi, M., El Far, O., Betz, H. FEBS Lett. (2000) [Pubmed]
  9. Expression of the onconeural CV2/CRMP5 antigen in thymus and thymoma. Camdessanché, J.P., Lassablière, F., Meyronnet, D., Férraud, K., Absi, L., Honnorat, J., Antoine, J.C. J. Neuroimmunol. (2006) [Pubmed]
  10. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Charrier, E., Reibel, S., Rogemond, V., Aguera, M., Thomasset, N., Honnorat, J. Mol. Neurobiol. (2003) [Pubmed]
  11. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. Ricard, D., Rogemond, V., Charrier, E., Aguera, M., Bagnard, D., Belin, M.F., Thomasset, N., Honnorat, J. J. Neurosci. (2001) [Pubmed]
  12. Autoantibody profiles and neurological correlations of thymoma. Vernino, S., Lennon, V.A. Clin. Cancer Res. (2004) [Pubmed]
  13. The 12,13-diol cyclization approach for a truly stereocontrolled total synthesis of epothilone B and the synthesis of a conformationally restrained analogue. Martin, H.J., Pojarliev, P., Kählig, H., Mulzer, J. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
  14. Remarkable efficiency of the aryne chemistry of (dehydro)octafluoro[2.2]paracyclophane when using the Cadogan method. Dolbier, W.R., Zhai, Y.A., Wheelus, W., Battiste, M.A., Ghiviriga, I., Bartberger, M.D. J. Org. Chem. (2007) [Pubmed]
  15. Immune-mediated autonomic neuropathies. Etienne, M., Weimer, L.H. Current neurology and neuroscience reports. (2006) [Pubmed]
  16. Computer-aided design of artificial enzymes: cyclic urea mimetics of alpha-chymotrypsin. Venanzi, C.A., Bunce, J.D. Enzyme (1986) [Pubmed]
  17. The Nramp orthologue of Cryptococcus neoformans is a pH-dependent transporter of manganese, iron, cobalt and nickel. Agranoff, D., Collins, L., Kehres, D., Harrison, T., Maguire, M., Krishna, S. Biochem. J. (2005) [Pubmed]
  18. Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung. Thambisetty, M.R., Scherzer, C.R., Yu, Z., Lennon, V.A., Newman, N.J. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. (2001) [Pubmed]
  19. Ocular manifestations and treatment of central nervous system lymphomas. G??nd??z, K., Pulido, J.S., McCannel, C.A., O'Neill, B.P. Neurosurgical focus (2006) [Pubmed]
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