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MeSH Review

Serologic Tests

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Disease relevance of Serologic Tests


Psychiatry related information on Serologic Tests

  • The following parameters were measured: pain as assessed by visual analogue scale; range of joint movements; grip strength; duration of early morning stiffness, joint circumference, Jebsen's hand assessment; drug usage; total swollen joint counts; Arthritis Impact Measurement Scales; three phase bone scans; haematological and serological tests [6].

High impact information on Serologic Tests

  • This attractive hypothesis, which has been widely accepted, was based on the assumption that serological tests using antisera raised against male cells were recognizing H-Y antigen [7].
  • Serological test systems were established for determining the heavy-chain variable region (Vh) subgroups of immunoglobulin heavy chains [8].
  • The diagnostic accuracy of serologic tests for celiac disease: a systematic review [3].
  • The aim of this study was to conduct a systematic review of the diagnostic performance of serologic tests for the diagnosis and screening of CD [3].
  • However, because serodiagnosis fails in 5%-10% and radiological techniques are difficult to interpret in some cases, we developed a polymerase chain reaction for the detection of echinococcal-specific messenger RNA from fine-needle biopsy specimens [9].

Chemical compound and disease context of Serologic Tests


Biological context of Serologic Tests


Anatomical context of Serologic Tests


Associations of Serologic Tests with chemical compounds

  • However, with the exception of depressed C3 levels, the sensitivity, specificity, and predictive values of all the serologic tests were low [25].
  • Serological tests were compatible with exposure to aluminium hydroxide-containing vaccines [26].
  • This study aimed to assess and compare the efficacy of the following H pylori serological tests in patients treated or not treated with non-steroidal anti-inflammatory drugs (NSAID): Pyloriset Latex, Helico-G, Biolab Malakit, and Bio-Rad GAP Test IgG [27].
  • Viral hepatitis serologic test results, acetaminophen levels, drug and alcohol screening findings, and bacterial and fungal cultures were negative in all 3 patients [28].
  • BACKGROUND: Allergen challenges are useful in adjudicating discordant clinical histories and skin test responses, serologic test responses, or both, as well as in determining the degree of allergic reactivity [29].

Gene context of Serologic Tests

  • C4A allotypes that express Ch1 and Ch3 rather than Rg1 and Rg2, and C4B allotypes that express Rg1 rather than Ch1, Ch2, or Ch3 confirmed that the inhibition specificity in serologic tests was anti-Ch1 and not anti-C4B [30].
  • The resultant neural network assignments were compared with those of a validation set containing the sequences of 74 HLA-A, 175 HLA-B, and 117 HLA-DRB1 alleles that had previous serologic test assignments but were not part of the training set [31].
  • Furthermore, various studies demonstrated that GPC3 could be used as a serological test for the diagnosis of patients with HCC [32].
  • The identification of tissue transglutaminase (TGA)-2 as the antigen against which the autoantibodies are directed has led to a greater understanding of the pathogenesis of CD and to the development of improved serological tests [33].
  • DNA typing confirmed the RhD-negative type of one AIHA sample in which serological tests were inconclusive [34].

Analytical, diagnostic and therapeutic context of Serologic Tests


  1. Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. Fikrig, E., Barthold, S.W., Sun, W., Feng, W., Telford, S.R., Flavell, R.A. Immunity (1997) [Pubmed]
  2. Antibodies to lipopolysaccharides of Escherichia coli serogroups O5 and O165 in healthy adults. Jenkins, C., Chart, H. Lancet (1999) [Pubmed]
  3. The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Rostom, A., Dubé, C., Cranney, A., Saloojee, N., Sy, R., Garritty, C., Sampson, M., Zhang, L., Yazdi, F., Mamaladze, V., Pan, I., MacNeil, J., Mack, D., Patel, D., Moher, D. Gastroenterology (2005) [Pubmed]
  4. Pneumonia associated with the TWAR strain of Chlamydia. Marrie, T.J., Grayston, J.T., Wang, S.P., Kuo, C.C. Ann. Intern. Med. (1987) [Pubmed]
  5. Legionnaires' disease and hairy-cell leukemia. An unfortuitous association? Cordonnier, C., Farcet, J.P., Desforges, L., Brun-Buisson, C., Vernant, J.P., Kuentz, M., Dournon, E. Arch. Intern. Med. (1984) [Pubmed]
  6. A double blind randomised trial of low power laser treatment in rheumatoid arthritis. Heussler, J.K., Hinchey, G., Margiotta, E., Quinn, R., Butler, P., Martin, J., Sturgess, A.D. Ann. Rheum. Dis. (1993) [Pubmed]
  7. Spermatogenic failure in male mice lacking H-Y antigen. Burgoyne, P.S., Levy, E.R., McLaren, A. Nature (1986) [Pubmed]
  8. Serological detection of variable region (Vh) subgroups of Ig heavy chains. Forre, O., Natvig, J.B., Kunkel, H.G. J. Exp. Med. (1976) [Pubmed]
  9. Diagnosis of Echinococcus multilocularis infection by reverse-transcription polymerase chain reaction. Kern, P., Frosch, P., Helbig, M., Wechsler, J.G., Usadel, S., Beckh, K., Kunz, R., Lucius, R., Frosch, M. Gastroenterology (1995) [Pubmed]
  10. Cloning and expression of the gene which encodes a tube precipitin antigen and wall-associated beta-glucosidase of Coccidioides immitis. Hung, C.Y., Yu, J.J., Lehmann, P.F., Cole, G.T. Infect. Immun. (2001) [Pubmed]
  11. Molecular approach to the epidemiology of swine vesicular disease: correlation of variation in the virus structural polypeptides with serological properties. Harris, T.J., Underwood, B.O., Knowles, N.J., Crowther, J.R., Brown, F. Infect. Immun. (1979) [Pubmed]
  12. Use of rMPB70 protein and ESAT-6 peptide as antigens for comparison of the enzyme-linked immunosorbent, immunochromatographic, and latex bead agglutination assays for serodiagnosis of bovine tuberculosis. Koo, H.C., Park, Y.H., Ahn, J., Waters, W.R., Palmer, M.V., Hamilton, M.J., Barrington, G., Mosaad, A.A., Park, K.T., Jung, W.K., Hwang, I.Y., Cho, S.N., Shin, S.J., Davis, W.C. J. Clin. Microbiol. (2005) [Pubmed]
  13. Validation of Legionella pneumophila indirect immunofluorescence assay with epidemic sera. Wilkinson, H.W., Cruce, D.D., Broome, C.V. J. Clin. Microbiol. (1981) [Pubmed]
  14. Cytotoxic drug treatment of lupus nephritis. Donadio, J.V., Holley, K.E., Ilstrup, D.M. Am. J. Kidney Dis. (1982) [Pubmed]
  15. Structural elucidation of the Brucella melitensis M antigen by high-resolution NMR at 500 MHz. Bundle, D.R., Cherwonogrodzky, J.W., Perry, M.B. Biochemistry (1987) [Pubmed]
  16. Evaluation of automated RNA-extraction technology and a qualitative HCV assay for sensitivity and detection of HCV RNA in pool-screening systems. Beld, M., Habibuw, M.R., Rebers, S.P., Boom, R., Reesink, H.W. Transfusion (2000) [Pubmed]
  17. Development, implementation, and impact of acceptability criteria for serologic tests for infectious diseases. Crump, J.A., Corder, J.R., Henshaw, N.G., Reller, L.B. J. Clin. Microbiol. (2004) [Pubmed]
  18. Differentiation of human immunodeficiency virus type 1 (HIV-1) infections with HIV-2-cross-reacting antibody from mixed infections with HIV-1 and HIV-2 by serological absorption test. Imai, M., Hayashi, T., Kondo, M., Saito, T., Ito, A., Hayami, M., Nishioka, K. J. Clin. Microbiol. (1995) [Pubmed]
  19. Species-specific serodiagnosis of Lyme arthritis and neuroborreliosis due to Borrelia burgdorferi sensu stricto, B. afzelii, and B. garinii by using decorin binding protein A. Heikkilä, T., Seppälä, I., Saxen, H., Panelius, J., Yrjänäinen, H., Lahdenne, P. J. Clin. Microbiol. (2002) [Pubmed]
  20. Nonsevere community-acquired pneumonia: correlation between cause and severity or comorbidity. Falguera, M., Sacristán, O., Nogués, A., Ruiz-González, A., García, M., Manonelles, A., Rubio-Caballero, M. Arch. Intern. Med. (2001) [Pubmed]
  21. Histoplasma capsulatum infections of the central nervous system. A clinical review. Wheat, L.J., Batteiger, B.E., Sathapatayavongs, B. Medicine (Baltimore) (1990) [Pubmed]
  22. High prevalence of celiac sprue-like HLA-DQ genes and enteropathy in patients with the microscopic colitis syndrome. Fine, K.D., Do, K., Schulte, K., Ogunji, F., Guerra, R., Osowski, L., McCormack, J. Am. J. Gastroenterol. (2000) [Pubmed]
  23. Hepatitis C infection and B-cell non-Hodgkin's lymphoma in British Columbia: a cross-sectional analysis. Shariff, S., Yoshida, E.M., Gascoyne, R.D., Le, N., Connors, J.M., Middleton, P.J., Shenkier, T.N. Ann. Oncol. (1999) [Pubmed]
  24. Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families. Book, L., Zone, J.J., Neuhausen, S.L. Am. J. Gastroenterol. (2003) [Pubmed]
  25. The value of complement and immune complex determinations in monitoring disease activity in patients with systemic lupus erythematosus. Valentijn, R.M., van Overhagen, H., Hazevoet, H.M., Hermans, J., Cats, A., Daha, M.R., van ES, L.A. Arthritis Rheum. (1985) [Pubmed]
  26. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. Gherardi, R.K., Coquet, M., Cherin, P., Belec, L., Moretto, P., Dreyfus, P.A., Pellissier, J.F., Chariot, P., Authier, F.J. Brain (2001) [Pubmed]
  27. Serological diagnosis of Helicobacter pylori--evaluation of four tests in the presence or absence of non-steroidal anti-inflammatory drugs. Taha, A.S., Reid, J., Boothmann, P., Gemmell, C.G., Lee, F.D., Sturrock, R.D., Russell, R.I. Gut (1993) [Pubmed]
  28. Hepatic decompensation in patients with cirrhosis during infection with influenza A. Duchini, A., Viernes, M.E., Nyberg, L.M., Hendry, R.M., Pockros, P.J. Arch. Intern. Med. (2000) [Pubmed]
  29. A hooded exposure chamber method for semiquantitative latex aeroallergen challenge. Kurtz, K.M., Hamilton, R.G., Schaefer, J.A., Adkinson, N.F. J. Allergy Clin. Immunol. (2001) [Pubmed]
  30. A monoclonal anti-C4d that demonstrates a specificity related to anti-Ch. Giles, C.M., Ford, D.S. Transfusion (1986) [Pubmed]
  31. Use of a neural network to assign serologic specificities to HLA-A, -B and -DRB1 allelic products. Maiers, M., Schreuder, G.M., Lau, M., Marsh, S.G., Fernandez-Viña, M., Noreen, H., Setterholm, M., Katovich Hurley, C. Tissue Antigens (2003) [Pubmed]
  32. Glypican-3 and alphafetoprotein as diagnostic tests for hepatocellular carcinoma. Filmus, J., Capurro, M. Mol. Diagn. (2004) [Pubmed]
  33. Anti-tissue transglutaminase antibodies and their role in the investigation of coeliac disease. Hill, P.G., McMillan, S.A. Ann. Clin. Biochem. (2006) [Pubmed]
  34. Molecular determination of RhD phenotype by DNA typing: clinical applications. Cotorruelo, C., Biondi, C., Borrás, S.G., Galizzi, S., Di Mónaco, R., Racca, A. Ann. Clin. Biochem. (2000) [Pubmed]
  35. Disseminated histoplasmosis in the acquired immune deficiency syndrome: clinical findings, diagnosis and treatment, and review of the literature. Wheat, L.J., Connolly-Stringfield, P.A., Baker, R.L., Curfman, M.F., Eads, M.E., Israel, K.S., Norris, S.A., Webb, D.H., Zeckel, M.L. Medicine (Baltimore) (1990) [Pubmed]
  36. Detection of coccidioidal antibodies by 33-kDa spherule antigen, Coccidioides EIA, and standard serologic tests in sera from patients evaluated for coccidioidomycosis. Wieden, M.A., Lundergan, L.L., Blum, J., Delgado, K.L., Coolbaugh, R., Howard, R., Peng, T., Pugh, E., Reis, N., Theis, J., Galgiani, J.N. J. Infect. Dis. (1996) [Pubmed]
  37. Immune responses in eight patients infected with Bacteroides fragilis. Lambe, D.W., Danielsson, D., Vroon, D.H., Carver, R.K. J. Infect. Dis. (1975) [Pubmed]
  38. Value of bacterial antigen detection in the diagnostic yield of transthoracic needle aspiration in severe community acquired pneumonia. Bella, F., Tort, J., Morera, M.A., Espaulella, J., Armengol, J. Thorax (1993) [Pubmed]
  39. Laboratory markers of tumor burden in nasopharyngeal carcinoma: a comparison of viral load and serologic tests for Epstein-Barr virus. Fan, H., Nicholls, J., Chua, D., Chan, K.H., Sham, J., Lee, S., Gulley, M.L. Int. J. Cancer (2004) [Pubmed]
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