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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin.

BACKGROUND: Vascular endothelial cadherin (VE-cadherin/cadherin-5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular architecture. Matrix-bound fibroblasts have been show to produce a number of factors that are important in inducing angiogenesis and to promote tubule-formation by human endothelial cells, an indicator of angiogenic potential. RESULTS: Tubule formation stimulated by fibroblast-derived growth factors can be prevented by the addition of monoclonal antibody to VE-cadherin. In addition, fibroblasts-derived growth factors are able to modulate the expression and hence the regulation of this endothelial cell specific cadherin. CONCLUSIONS: The change in VE-cadherin expression of human endothelial cells by fibroblast-derived growth factors may contribute to the regulation of angiogenesis.[1]


  1. Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin. Martin, T.A., Harding, K., Jiang, W.G. Eur. J. Clin. Invest. (2001) [Pubmed]
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