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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Napoletano, M. et al.

Napoletano, Norcini, Pellacini, Marchini, Morazzoni, Fattori, Ferlenga, Pradella,

Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.

This communication describes the synthesis and in vitro evaluation of a novel and potent series of phthalazine phosphodiesterase type (IV) (PDE4) inhibitors. The interaction with two distinct polar binding sites allowed us to eliminate the cyclopentyloxy substitution from rolipram-like analogues.[1]

References

Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor. Napoletano, M., Norcini, G., Pellacini, F., Marchini, F., Morazzoni, G., Fattori, R., Ferlenga, P., Pradella, L. Bioorg. Med. Chem. Lett. (2002) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg